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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-09-21
    Description: High-resolution autoradiography and fine structural analysis of adult newt heart tissue in long-term culture revealed that tritiated thymidine was concentrated in the nuclei of dedifferentiated myocardial cells. Mitotic chromosomes were observed in some of these cells. This demonstrates that adult amphibian myocardial cells in vitro are capable of DNA synthesis and mitosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nag, A C -- Healy, C J -- Cheng, M -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1281-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472744" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; *Mitosis ; Muscle Proteins/metabolism ; Myocardial Contraction ; Myocardium/*metabolism ; Salamandridae ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-06-06
    Description: Dissociated embryonic rat myocardial cells and chick myocardial cells labeled with radioactive isotope coaggregate and establish intercellular junctions. These bispecific cells reconstruct synchronously beating myocardial tissue within 24 hours of culture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nag, A C -- Cheng, M -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1150-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; *Cell Aggregation ; Cells, Cultured ; Chickens ; Heart/*embryology ; Intercellular Junctions/ultrastructure ; Mosaicism ; Myocardial Contraction ; Myocardium/*cytology ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1984-05-18
    Description: DNA replication in mammals is temporally bimodal. "Housekeeping" genes, which are active in all cells, replicate during the first half of the S phase of cell growth. Tissue-specific genes replicate early in those cells in which they are potentially expressed, and they usually replicate late in tissues in which they are not expressed. Replication during the first half of the S phase is, therefore, a necessary but not sufficient condition for gene transcription. A change in the replication timing of a tissue-specific gene appears to reflect the commitment of that gene to transcriptional competence or to quiescence during ontogeny. Most families of middle repetitive sequences replicate either early or late. These data are consistent with a model in which two functionally distinct genomes coexist in the nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, M A -- Holmquist, G P -- Gray, M C -- Caston, L A -- Nag, A -- GM 07526/GM/NIGMS NIH HHS/ -- GM23905/GM/NIGMS NIH HHS/ -- K04 HD 00323/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1984 May 18;224(4650):686-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719109" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Chromatin/physiology ; Cricetinae ; DNA/physiology ; *DNA Replication ; *Genes ; HeLa Cells/metabolism ; Humans ; Nucleic Acid Hybridization ; *Repetitive Sequences, Nucleic Acid ; Replicon ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Earth Resources and Remote Sensing
    Type: GSFC-E-DAA-TN33613
    Format: application/pdf
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  • 5
    Publication Date: 2019-07-13
    Description: As technology has improved, operators have sought to use cubesats, as well as smallsats more generally, to perform increasingly more ambitious and sophisticated functions. Despite this, practical concerns associated with cubesat infant mortality, conjunctions, limited maneuverability, and debris generation have been relatively muted because most cubesats have been launched to lower orbits that limit both their orbital lifetime and consequences should a collision occur. NASA ARC has developed a concept for a highly-automated and distributed space traffic management (STM) architecture, drawing on similar work done to provide traffic management for small unmanned aerial systems (UAS) operating at low altitudes. The system proposes a strategy to accommodate growing space traffic volume safely, as well as pave the way for a transition of civil STM authority to a civilian governmental entity. The architecture envisions an open-access software platform architecture of data and service suppliers, consumers, and regulators, connected via a set of application programming interfaces (APIs). The platform would build on, rather than replicate existing integration and coordination efforts within the space situational awareness ecosystem, using existing standards for data message formats from organizations like the Consultative Committee for Space Data Systems and wrapping, rather than replacing existing integrations. We will present an initial STM architecture in this presentation, with a few examples showing how stakeholders can interact structurally, but flexibly, within this architecture.
    Keywords: Air Transportation and Safety
    Type: ARC-E-DAA-TN59948 , Small Satellite Conference; Aug 04, 2018 - Aug 09, 2018; Logan, UT; United States
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  • 6
    Publication Date: 2019-07-13
    Description: NASA is developing the Unmanned Aircraft System Traffic Management research platform to safely integrate small unmanned aircraft operations in large-scale at low-altitudes. As a part of this effort, small unmanned aircraft system off-nominal operational situations data collection process has been developed to take lessons learned and to reinforce operational compliance. In this paper, descriptions of variables used for digital data collection and an online report form for collection of observational data from the operators (contextual data) are provided. They are used to collect off-nominal data from the Unmanned Aircraft System Traffic Management National Campaign in 2017. The digital data show that 2 out of 118 campaign operations (1.7%) encountered loss of navigation. Since the campaign aircraft used Global Positioning System for navigation, it is likely that unobstructed view of the sky at the campaign locations contributed to this small number. Also, 4 out of 47 operations (8.5%) encountered loss of communications. A relatively short distance between ground control system and aircraft, ranging from 2300 feet to 4200 feet, likely contributed to this small number. There was no data to identify the loss of communications condition, aircraft received signal strength, for the remaining 71 operations suggesting that some operators may not be monitoring unmanned aircraft communications system performance or monitoring it with different parameters. For the contextual data, due to the low number of total reports during the campaign, no significant trends emerged. This is an initial attempt to collect contextual data from small unmanned aircraft operators about off-nominal situations, and changes will be made to the future data collection to improve the amount and quality of the information.
    Keywords: Air Transportation and Safety
    Type: ARC-E-DAA-TN57430 , Aviation Forum 2018; Jun 25, 2018 - Jun 29, 2018; Atlanta, GA; United States
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  • 7
    Publication Date: 2019-08-14
    Description: We confirm the applicability of using small satellite formation flight for multi-angular earth observation to retrieve global, narrow band, narrow field-of-view albedo. The value of formation flight is assessed using a coupled systems engineering and science evaluation model, driven by Model Based Systems Engineering and Observing System Simulation Experiments. Albedo errors are calculated against bi-directional reflectance data obtained from NASA airborne campaigns made by the Cloud Absorption Radiometer for the seven major surface types, binned using MODIS' land cover map - water, forest, cropland, grassland, snow, desert and cities. A full tradespace of architectures with three to eight satellites, maintainable orbits and imaging modes (collective payload pointing strategies) are assessed. For an arbitrary 4-sat formation, changing the reference, nadir-pointing satellite dynamically reduces the average albedo error to 0.003, from 0.006 found in the static reference case. Tracking pre-selected waypoints with all the satellites reduces the average error further to 0.001, allows better polar imaging and continued operations even with a broken formation. An albedo error of 0.001 translates to 1.36 W/sq m or 0.4% in Earth's outgoing radiation error. Estimation errors are found to be independent of the satellites' altitude and inclination, if the nadir-looking is changed dynamically. The formation satellites are restricted to differ in only right ascension of planes and mean anomalies within slotted bounds. Three satellites in some specific formations show average albedo errors of less than 2% with respect to airborne, ground data and seven satellites in any slotted formation outperform the monolithic error of 3.6%. In fact, the maximum possible albedo error, purely based on angular sampling, of 12% for monoliths is outperformed by a five-satellite formation in any slotted arrangement and an eight satellite formation can bring that error down four fold to 3%. More than 70% ground spot overlap between the satellites is possible with 0.5deg of pointing accuracy, 2 Km of GPS accuracy and commands uplinked once a day. The formations can be maintained at less than 1 m/s of monthly (Delta)V per satellite.
    Keywords: Earth Resources and Remote Sensing
    Type: GSFC-E-DAA-TN32486 , Acta Astronautica (ISSN 0094-5765); o 126; 77-97
    Format: text
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  • 8
    Publication Date: 2019-09-04
    Description: No abstract available
    Keywords: Earth Resources and Remote Sensing
    Type: GSFC-E-DAA-TN72747 , IGARSS 2019; Jul 28, 2019 - Aug 02, 2019; Yokohama; Japan
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  • 9
    Publication Date: 2019-07-13
    Description: Multispectral snapshot imagers are capable of producing 2D spatial images with a single exposure at selected, numerous wavelengths using the same camera, therefore operate differently from push broom or whiskbroom imagers. They are payloads of choice in multi-angular, multi-spectral imaging missions that use small satellites flying in controlled formation, to retrieve Earth science measurements dependent on the targets Bidirectional Reflectance-Distribution Function (BRDF). Narrow fields of view are needed to capture images with moderate spatial resolution. This paper quantifies the dependencies of the imagers optical system, spectral elements and camera on the requirements of the formation mission and their impact on performance metrics such as spectral range, swath and signal to noise ratio (SNR). All variables and metrics have been generated from a comprehensive, payload design tool. The baseline optical parameters selected (diameter 7 cm, focal length 10.5 cm, pixel size 20 micron, field of view 1.15 deg) and snapshot imaging technologies are available. The spectral components shortlisted were waveguide spectrometers, acousto-optic tunable filters (AOTF), electronically actuated Fabry-Perot interferometers, and integral field spectrographs. Qualitative evaluation favored AOTFs because of their low weight, small size, and flight heritage. Quantitative analysis showed that waveguide spectrometers perform better in terms of achievable swath (10-90 km) and SNR (greater than 20) for 86 wavebands, but the data volume generated will need very high bandwidth communication to downlink. AOTFs meet the external data volume caps well as the minimum spectral (wavebands) and radiometric (SNR) requirements, therefore are found to be currently feasible in spite of lower swath and SNR.
    Keywords: Earth Resources and Remote Sensing
    Type: GSFC-E-DAA-TN44164 , IEEE Sensors Journal (ISSN 1530-437X) (e-ISSN 1558-1748); 17; 16; 5252-5268
    Format: text
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  • 10
    Publication Date: 2019-11-08
    Description: NASA has been researching prototype technologies for an Unmanned Aircraft System (UAS) Traffic Management (UTM) system to facilitate enabling of safe and efficient civilian low-altitude airspace and UAS operations, in a series of Technical Capability Levels (TCL) activities that are increasingly complex. In TCL1, completed in 2015, visual line-of-sight operations such as agriculture, firefighting and infrastructure monitoring were addressed with a focus on geofencing and operations scheduling. Technologies and requirements needed for beyond visual line-of-sight (BVLOS) operations in sparsely populated areas were examined in TCL2 in 2016, and those for operations over moderately populated areas in TCL3 in 2017 and 2018. TCL4 will build on the earlier TCLs and focus on technologies and requirements for operations in higher-density urban areas for tasks such as news gathering, package delivery and for managing large-scale contingencies. This paper describes a communications test conducted in TCL3 and discusses insights gained from the test. In the test, operators were directed to equip UAS with redundant Command and Control (C2) communications systems, send a maneuver command to Unmanned Aircraft (UA) via the primary system, then verify execution of the sent command. This exercise was repeated with each redundant system. The test was designed to assess effectiveness of redundant C2 systems in maintaining operational control of UA. Several UAS were configured with varying arrangements to achieve redundancy, including two identical radio modems using the same frequency band, WiFi and Long-Term Evolution (LTE) cellular modems, etc. From the test, digital data such as time maneuver command sent, time maneuver verified, etc., were collected. Descriptions of methods to detect loss of C2 communications and contingency steps for such event were collected and assessed. The final paper will include a detailed analysis of the collected data leading to the following insights. First, effectiveness of redundant C2 systems depends on several factors, such as operational environment and communications service availability. For example, use of two identical point-to-point radio to connect operator and UA on the same frequency band can be effective in mitigating radio malfunction when operating in an environment where possibility of Radio Frequency (RF) interference is low, such as over open plains. However, the same arrangement may not be effective where high level of RF transmissions in broad spectrum ranges can be expected, such as over or near urban areas. For redundant systems that consist of external communications services, such as cellular and satellite communications network, redundancy is maintained only in the areas where more than one services are available. Therefore, UAS operators should have the means to plan for and monitor the performance of external communications services they are relying on to control UA. Second, communications performance needs, such as the minimum data transfer rate and the maximum tolerable latency, should be assessed to reflect the potential hazard that can come from loss of UA control. For example, UA operations over desolate area pose less hazard to people than operations over densely populated area and performance need for the former would be less than the latter.
    Keywords: Air Transportation and Safety
    Type: ARC-E-DAA-TN73288 , Digital Avionics Systems Conference (DASC); Sep 08, 2019 - Sep 12, 2019; San Diego, CA; United States
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