Publication Date:
2001-06-30
Description:
Plasticity of mature hippocampal CA1 synapses is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A(-/-) mice when (GFP)GluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mack, V -- Burnashev, N -- Kaiser, K M -- Rozov, A -- Jensen, V -- Hvalby, O -- Seeburg, P H -- Sakmann, B -- Sprengel, R -- New York, N.Y. -- Science. 2001 Jun 29;292(5526):2501-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Neurobiology, Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11431570" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Dendrites/metabolism
;
Doxycycline/pharmacology
;
Electric Stimulation
;
Excitatory Postsynaptic Potentials
;
Green Fluorescent Proteins
;
Hippocampus/metabolism/*physiology
;
*Long-Term Potentiation
;
Luminescent Proteins
;
Mice
;
Mice, Transgenic
;
Neuronal Plasticity
;
Patch-Clamp Techniques
;
Pyramidal Cells/metabolism/*physiology
;
Receptors, AMPA/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Synapses/metabolism/*physiology
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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