ISSN:
1572-8773
Keywords:
adenosine-5′-monophosphate and guanosine-5′-monophosphate cleavage
;
Ce(NH4)2(NO3)6 and Ce(SO4)2
;
lanthanide ions
;
lanthanide complexes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The cleavage of adenosine-5′-monophosphate (5′-AMP) and guanosine-5′-monophosphate (5′-GMP) by Ce4+ and lanthanide complex of 2-carboxyethylgermanium sesquioxide (Ge-132) in acidic and near neutral conditions was investigated by NMR , HPLC and measuring the liberated inorganic phosphate at 37°C and 50°C. The results showed that 5′-GMP and 5′-AMP was converted to guanine (G), 5′-monophosphate (depurination of 5′-GMP), ribose (depurination and dephosphorylation of 5′-GMP), phosphate and adenine (A), 5′-monophosphate (depurination of 5′-AMP), ribose (depurination and dephosphorylation of 5′-AMP), phosphate respectively by Ce4+. In presence of lanthanide complexes, 5′-GMP and 5′-AMP were converted to guanosine (Guo) and phosphate and adenosine (Ado) and phosphate respectively. The mechanism of cleaving 5′-GMP and 5′-AMP is hydrolytic scission
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009286527492
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