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  • 1
    Publication Date: 2018-06-11
    Description: In several studies we tested the concepts that diet can alter acid-base balance and that reducing the dietary acid load has a positive effect on maintenance of bone. In study 1, (n = 11, 60-90 d bed rest), the renal acid load of the diet was estimated from its chemical composition, and was positively correlated with urinary markers of bone resorption (P less than 0.05); that is, the greater the acid load, the greater the excretion of bone resorption markers. In study 2, in males (n = 8, 30 d bed rest), an estimate of the ratio of nonvolatile acid precursors to base precursors in the diet was positively correlated (P less than 0.05) with markers of bone resorption. In study 3, for 28 d subjects received either a placebo (n = 6) or an essential amino acid supplement (n = 7) that included methionine, a known acid precursor. During bed rest (28 d), urinary calcium was greater than baseline levels in the supplemented group but not the control group (P less than 0.05), and in the supplemented group, urinary pH decreased (P less than 0.05). In study 4, less bone resorption occurred in space crew members who received potassium citrate (n = 6) during spaceflight of 4-6 months than in crew members who received placebo or were not in the study (n = 8) (P less than 0.05). Reducing acid load has the potential to mitigate increased bone resorption during spaceflight, and may serve as a bone loss countermeasure.
    Keywords: Aerospace Medicine
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  • 2
    Publication Date: 2018-06-11
    Description: In estimating the crew exposures during an EVA, the contribution of reentrant electrons has always been neglected. Although the flux of these electrons is small compared to the flux of trapped electrons, their energy spectrum extends to several GeV compared to about 7 MeV for trapped electrons. This is also true of splash electrons. Using the measured reentrant electron energy spectra, it is shown that the dose contribution of these electrons to the blood forming organs (BFO) is more than 10 times greater than that from the trapped electrons. The calculations also show that the dose-depth response is a very slowly changing function of depth, and thus adding reasonable amounts of additional shielding would not significantly lower the dose to BFO.
    Keywords: Aerospace Medicine
    Type: Radiation Measurements; 121-126
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  • 3
    Publication Date: 2019-07-19
    Description: Energetic neutron measurements remain a challenge for space science investigations and radiation monitoring for human exploration beyond LEO. We are investigating a new composite scintillator design that uses Li6 glass scintillator embedded in a PVT block. A comparison between Li6 and Boron 10 loaded scintillators are being studied to assess the advantages and shortcomings of these two techniques. We present the details of the new Li6 design and results from the comparison of the B10 and Li6 techniques during exposures in a mixed radiation field produced by high energy protons interacting in a target material.
    Keywords: Aerospace Medicine
    Type: M13-2472 , International Cosmic Ray Conference ((ICRC); Jul 02, 2013 - Jul 09, 2013; Rio de Janeiro; Brazil
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  • 4
    Publication Date: 2019-07-13
    Description: Significant absorbed dose levels exceeding 1.0 Gy day-1 have been measured on the external surface of the Cosmos 1887 biosatellite as functions of depth in stacks of thin thermoluminescent detectors (TLDs) of U.S.S.R. and U.S.A. manufacture. The dose was found to decrease rapidly with increasing absorber thickness, thereby indicating the presence of intensive fluxes of low-energy particles. Comparison between the U.S.S.R. and U.S.A. results and calculations based on the Vette Model environment are in satisfactory agreement. The major contribution to the dose under thin shielding thickness is shown to be from electrons. The fraction of the dose due to protons and heavier charged particles increases with shielding thickness.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 17; 2; 105-7
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  • 5
    Publication Date: 2019-07-13
    Description: Integral linear energy transfer (LET) spectra of cosmic radiation (CR) particles were measured on five Cosmos series spacecraft in low Earth orbit (LEO). Particular emphasis is placed on results of the Cosmos 1887 biosatellite which carried a set of joint U.S.S.R.-U.S.A. radiation experiments involving passive detectors that included thermoluminescent detectors (TLDs), plastic nuclear track detectors (PNTDs), fission foils, nuclear photo-emulsions, etc. which were located both inside and outside the spacecraft. Measured LET spectra are compared with those theoretically calculated. Results show that there is some dependence of LET spectra on orbital parameters. The results are used to estimate the CR quality factor (QF) for the Cosmos 1887 mission.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 17; 2; 93-7
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  • 6
    Publication Date: 2019-07-13
    Description: Develop a compact low-power neutron spectrometer that uniquely identifies neutrons in the mixed radiation field expected on crewed deep-space missions. Secondary neutrons are generated by cosmic rays striking heavy crewed spacecraft as well as lunar and planetary surfaces1,2. It has been shown that secondary neutrons can account for up to 50% if the total dose-equivalent received by the crew.
    Keywords: Aerospace Medicine
    Type: M14-3918 , Committee on Space Research (COSPAR) Scientific Assembly; Aug 02, 2014 - Aug 10, 2014; Moscow; Russia
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  • 7
    Publication Date: 2019-07-13
    Description: During the flight of the Cosmos-2044 biosatellite, joint U.S.S.R.-U.S.A. investigations of different characteristics of cosmic radiation (CR) in the near-Earth environment were carried out. The U.S. dielectric track detectors CR-39 and Soviet BYa- and BR-type nuclear photo-emulsions were used as detectors. The present work shows some results of experimental measurements of linear energy transfer (LET) spectra of CR particles obtained with the use of these detectors, which were placed both inside and outside the satellite. The LET spectra measurement with plastic detectors is composed of two parts: the measurement of galactic cosmic rays (GCR) particles, and of short-range particles. The contributions of these components to the total LET distribution at various thicknesses of the shielding were analyzed and the results of these studies are presented. Calculated LET spectra in the Cosmos-2044 orbit were compared with experimental data. On the basis of experimental and calculated values of the LET spectra, absorbed and equivalent CR doses were calculated. In the shielding range of 1-1.5 g cm-2, outside the spacecraft, the photo-emulsions yielded 10.3 mrad d-1 and 27.5 mrem d-1 (LET 〉 or = 2 MeV cm-1) while the CR-39 yielded averages of 1.43 mrad d-1 and 13.4 mrem d-1 (LET 〉 or = 40 MeV cm-1). Inside the spacecraft (〉 or = 10 g cm-2) the photo-emulsions yielded 8.9 mrad d-1 and 14.5 mrem d-1.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 20; 1; 143-7
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  • 8
    Publication Date: 2019-07-13
    Description: Results of the experiments on board Cosmos-2044 (Biosatellite 9) are presented. Various nuclear track detectors (NTD) (dielectric, AgCl-based, nuclear emulsions) were used to obtain the LET spectra inside and outside the satellite. The spectra from the different NTDs have proved to be in general agreement. The results of LET spectra calculations using two different models are also presented. The resultant LET distributions are used to calculate the absorbed and equivalent doses and the orbit-averaged quality factors (QF) of the cosmic rays (CR). Absorbed dose rates inside (approximately 20 g cm-2 shielding) and outside (1 g cm-2) the spacecraft, omitting electrons, were found to be 4.8 and 8.6 mrad d-1, respectively, while the corresponding equivalent doses were 8.8 and 19.7 mrem d-1. The effects of the flight parameters on the total fluence of, and on the dose from, the CR particles are analyzed. Integral dose distributions of the detected particles are also determined. The LET values which separate absorbed and equivalent doses into 50% intervals are estimated. The CR-39 dielectric NTD is shown to detect 20-30% of the absorbed dose and 60-70% of the equivalent dose in the Cosmos-2044 orbit. The influence of solar activity phase on the magnitude of CR flux is discussed.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 20; 1; 149-55
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  • 9
    Publication Date: 2019-07-13
    Description: The long duration exposure facility (LDEF), launched into a 258 nautical mile orbit with an inclination of 28.5 degrees, remained in space for nearly 6 yr. The 21,500 lb NASA satellite was one of the largest payloads ever deployed by the Space Shuttle. LDEF completed 32,422 orbits and carried 57 major experiments representing more than 200 investigators from 33 private companies, 21 universities and nine countries. The experiments covered a wide range of disciplines including basic science, electronics, optics, materials, structures and power and propulsion. A number of the experiments were specifically designed to measure the radiation environment. These experiments are of specific interest, since the LDEF orbit is essentially the same as that of the Space Station Freedom. Consequently, the radiation measurements on LDEF will play a significant role in the design of radiation shielding of the space station. The contributions of the various authors presented here attempt to predict the major aspects of the radiation exposure received by the various LDEF experiments and therefore should be helpful to investigators who are in the process of analyzing experiments which may have been affected by exposure to ionizing radiation. The paper discusses the various types and sources of ionizing radiation including cosmic rays, trapped particles (both protons and electrons) and secondary particles (including neutrons, spallation products and high-LET recoils), as well as doses and LET spectra as a function of shielding. Projections of the induced radioactivity of LDEF are also discussed.
    Keywords: Aerospace Medicine
    Type: International Journal Of Radiation Applications And Instrumentation. Part D, Nuclear Tracks And Radiation Measurements (ISSN 0735-245X); 20; 1; 75-100
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  • 10
    Publication Date: 2019-07-13
    Description: A large number of astronauts returning from spaceflight experience orthostatic hypotension. This hypotension may be due to overproduction of vasodilatory mediators, such as nitric oxide (NO) and prostaglandins. To evaluate the role of the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) as a countermeasure against the post-suspension reduction in mean arterial pressure (MAP), we assessed the cardiovascular responses and vascular reactivity to 7-day 30 degrees tail-suspension and a subsequent 6 hr post-suspension period in conscious rats. After a pre-suspension reading, direct MAP and heart rate (HR) were measured daily and every 2 hrs post-suspension. The NO synthase inhibitor L-NAME (20 mg/kg, i.v.), or saline, were administered after the 7th day reading prior to release from suspension and at 2 and 4 hrs post-suspension. At 6 hrs post-suspension, vascular reactivity was assessed. While MAP did not change during the suspension period, it was reduced post-suspension. Heart rate was not significantly altered. L-NAME administration reversed the post-suspension reduction in MAP. In addition, the baroreflex sensitivity for heart rate was modified by L-NAME. Thus, the post-suspension reduction in MAP may be due to overproduction of NO and altered baroreflex activity.
    Keywords: Aerospace Medicine
    Type: Clinical and experimental hypertension (New York, N.Y. : 1993) (ISSN 1064-1963); 23; 8; 611-22
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