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  • 1
    Electronic Resource
    Electronic Resource
    Tryptophanbestimmung im Gehirn Spezifische fluorimetrische Methode in Gegenwart von Analoga und Metaboliten (1978)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 293 (1978), S. 407-409 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Tryptophan in Gehirn ; Chromatographie, Dünnschicht/Fluorimetrie ; neben Metaboliten und Derivaten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wurde eine Methode zur Bestimmung von Tryptophan in Gehirn ausgearbeitet. Diese führt in Gegenwart von Formaldehyd und Salpetersäure zu einem Fluorophor (Typ Norharman), der — im Gegensatz zu ähnlichen Formaldehydreaktionen mit HCl u. a. — nur von Tryptamin schwach gestört wird. Serotonin, 5-Hydroxytryptophan, Xanthurensäure, 3Hydroxyanthranilsäure und 5-Hydroxyindolessigsäure stören die fluorimetrische Bestimmung (374/450 nm) nicht. Es kann sogar auf vorherige DC-Trennung verzichtet werden. Geschlechts- und altersspezifische Unterschiede des Tryptophangehalts im Rattenhirn sind nicht stark ausgeprägt.
    Notes: Summary A method for the determination of tryptophan in the brain was developed, which is based on the formation of a fluorophore (374/450 nm) in the presence of formaldehyde and nitric acid. In contrast to similar methods which use formaldehyde and hydrochloric acid, tryptamine interferes only weakly. Serotonin, 5-hydroxytryptophan, xanthurenic acid, 3-hydroxyanthranilic acid and 5-hydroxyindoleacetic acid do not interfere, t.l.c. separation prior to fluorophore formation can be omitted. Influence of sex and age on the tryptophan content in rat brain are not very marked.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00471461
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  • 2
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    Comparison of Postural Recovery Following Short and Long Duration Spaceflights (2010)
    In:  CASI
    Details
    Publication Date: 2019-07-19
    Description: INTRODUCTION: Post-flight postural ataxia reflects adaptive changes to vestibulo-spinal reflexes and control strategies adopted for movement in weightlessness. Quantitative measures obtained during computerized dynamic posturography (CDP) from US and Russian programs provide insight into the effect of spaceflight duration in terms of both the initial decrements and recovery of postural stability. METHODS: CDP was obtained on 117 crewmembers following Shuttle flights lasting 4-17 days, and on 64 crewmembers following long-duration missions lasting 48-380 days. Although the number and timing of sessions varied, the goal was to characterize postural recovery pooling similar measures from different research and flight medicine programs. This report focuses on eyes closed, head erect conditions with either a fixed or sway-referenced base of support. A smaller subset of subjects repeated the sway-referenced condition while making pitch head movements (+/- 20deg at 0.33Hz). Equilibrium scores were derived from peak-to-peak anterior-posterior sway. Fall probability was modeled using Bayesian statistical methods to estimate parameters of a logit function. RESULTS: The standard Romberg condition was the least sensitive. Longer duration flights led to larger decrements in stability with sway-reference support during the first 1-2 days, although the timecourse of recovery was similar across flight duration with head erect. Head movements led to increased incidence of falls during the first week, with a significantly longer recovery following long duration flights. CONCLUSIONS: The diagnostic assessment of postural instability, and differences in the timecourse of postural recovery between short and long flight durations, are more pronounced during unstable support conditions requiring active head movements.
    Keywords: Aerospace Medicine
    Type: JSC-CN-22460 , 8th Symposium on the Role of the Vestibular Organs in Space Exploration; Apr 08, 2011 - Apr 10, 2011; Houston, TX; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Studying the MLT by a Combined Analysis of SABER/TIMED and Lidar Measurements (2006)
    In:  Other Sources
    Details
    Publication Date: 2019-07-19
    Description: The SABER instrument on board the TIMED Satellite is a limb scanning infrared radiometer designed to measure temperature and minor constituent vertical profiles and energetics parameters in the mesosphere and lower thermosphere (MLT). The measurements have been performed continuously since January 25, 2002 to provide excellent coverage for both hemispheres. The Leibniz-Institute of Atmospheric Physics (LAP) at Kuehlungsborn, Germany (54N, 12E) operates two lidar instruments, using three different temperature measurement methods, optimized for three altitude ranges. The total altitude range of the lidar installation lies from 1 to 105 km. Another instrument used for intercomparison is the ALOMAR RMR lidar, located at Andoya, Norway (69N, 16E). We have searched the SABER and lidar datasets for coincidental common volume measurements within plus or minus 1 degree in latitude, plus or minus 2 degrees in longitude and approx. 1 hour in time for the sake of (a) comparison of measured temperatures; (b) validation of the models used in SABER data analysis; and (c) extracting new information about MLT parameters. In this work we applied the non-LTE ALI-ARMS code designed to calculate the nonequilibrium radiance in different viewing geometries to the analysis of measurements which satisfied these search criteria. The results of this analysis (a) support the application of higher value of CO2-O quenching rate (6e-12 cubic centimeters per second) by the non-LTE temperature retrievals from the SABER 15 micrometer limb radiance data, and (b) demonstrate the importance of accounting for the vibrational-vibrational energy exchange among the CO2 isotopes for accurate temperature retrievals. Using temperature profiles obtained in lidar measurements as inputs for the retrieval algorithm we also retrieved the nighttime CO2 densities from the SABER 15 micrometer limb radiances and compared them with the model and climatology CO2 data used in the SABER nighttime temperature retrievals.
    Keywords: Meteorology and Climatology
    Type: 2006 AGU Fall Meeting; Dec 11, 2006 - Dec 15, 2006; San Francisco, CA; United States
    Format: text
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    NASA TECHNICAL REPORTS
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