Publication Date:
2019-07-13
Description:
To investigate ophthalmic changes in spaceflight, we would like to predict the impact of blood dysregulation and elevated intracranial pressure (ICP) on Intraocular Pressure (IOP). Unlike other physiological systems, there are very few lumped parameter models of the eye. The eye model described here is novel in its inclusion of the human choroid and retrobulbar subarachnoid space (rSAS), which are key elements in investigating the impact of increased ICP and ocular blood volume. Some ingenuity was required in modeling the blood and rSAS compartments due to the lack of quantitative data on essential hydrodynamic quantities, such as net choroidal volume and blood flowrate, inlet and exit pressures, and material properties, such as compliances between compartments.
Keywords:
Aerospace Medicine; Systems Analysis and Operations Research
Type:
GRC-E-DAA-TN20061
,
Human Research Program Investigators'' Workshop: Integrated Pathways to Mars; Jan 13, 2015 - Jan 15, 2015; Galveston, TX; United States
Format:
application/pdf
Permalink
