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  • Aerospace Medicine; Lunar and Planetary Science and Exploration  (1)
  • Space Radiation; Aerospace Medicine  (1)
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  • Aerospace Medicine; Lunar and Planetary Science and Exploration  (1)
  • Space Radiation; Aerospace Medicine  (1)
  • Aerospace Medicine  (5)
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  • 1
    Publication Date: 2019-08-13
    Description: Exploration-class missions to the moon, Mars and beyond will require a significant change in medical capability from today's low earth orbit centric paradigm. Significant increases in autonomy will be required due to differences in duration, distance and orbital mechanics. Aerospace medicine and systems engineering teams are working together within ExMC to meet these challenges. Identifying exploration medical system needs requires accounting for planned and unplanned medical care as defined in the concept of operations. In 2017, the ExMC Clinicians group identified medical capabilities to feed into the Systems Engineering process, including: determining what and how to address planned and preventive medical care; defining an Accepted Medical Condition List (AMCL) of conditions that may occur and a subset of those that can be treated effectively within the exploration environment; and listing the medical capabilities needed to treat those conditions in the AMCL. This presentation will discuss the team's approach to addressing these issues, as well as how the outputs of the clinical process impact the systems engineering effort.
    Keywords: Aerospace Medicine; Lunar and Planetary Science and Exploration
    Type: JSC-CN-40551 , Annual NASA Human Research Program Investigators'' Workshop (HRP IWS) 2018; Jan 22, 2018 - Jan 25, 2018; Galveston, TX; United States
    Format: application/pdf
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  • 2
    Publication Date: 2019-08-13
    Description: Historical studies performed by the JSC Pharmacotherapeutics Discipline suggest that exposure to spaceflight conditions may compromise the safety and efficacy of some medications. Follow-on studies have revealed that affected medications demonstrate reductions in active pharmaceutical ingredient (API) concentrations and altered release characteristics. It was hypothesized that the changes in API potency and release were from the medication's exposure to the harsh environmental conditions of spaceflight. Subsequent review of the spaceflight environmental control records from the time of these studies indicated that temperature and humidity levels aboard all spacecraft remained within United States Pharmacopeia (USP) recommended ranges to maintain optimal pharmaceutical stability. Therefore, space radiation was presumed to be the source of observed drug degradation. The Pharmacotherapeutics Discipline conducted a ground analog radiation experiment in 2006 at the NASA Space Radiation Laboratory (NSRL) at Brookhaven to validate this theory and to characterize the effects of high-energy radioactive particles on pharmaceutical stability. These data were never published. Recently, the Exploration Medical Capability (ExMC) Element finalized a research plan (RP) aimed at providing a safe and effective medication formulary for exploration spaceflight. As ExMC begins to design new flight and ground analog radiation studies, further analysis of the 2006 NSRL study data is essential for the characterization of the impact of radiation on medication potency and efficacy in the exploration spaceflight environment.
    Keywords: Space Radiation; Aerospace Medicine
    Type: JSC-CN-40553 , NASA Human Research Program Investigators'' Workshop (HRP IWS 2018); Jan 22, 2018 - Jan 25, 2018; Galveston, TX; United States
    Format: application/pdf
    Location Call Number Expected Availability
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