Publication Date:
2019-07-13
Description:
Microgravity and ionizing radiation in the spaceflight environment poses multiple challenges to homeostasis and may contribute to cellular stress. Effects may include increased generation of reactive oxygen species (ROS), DNA damage and repair error, cell cycle arrest, cell senescence or death. Our central hypothesis is that prolonged exposure to the spaceflight environment leads to the excess production of ROS and oxidative damage, culminating in accelerated tissue degeneration. The main goal of this project is to determine the importance of cellular redox defense for physiological adaptations and tissue degeneration in the space environment.
Keywords:
Aerospace Medicine; Life Sciences (General)
Type:
ARC-E-DAA-TN48022
,
Annual Meeting, American Society for Gravitational and Space Research (ASGSR 2017); Oct 25, 2017 - Oct 28, 2017; Seattle, WA; United States
Format:
application/pdf
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