Publication Date:
1997-12-31
Description:
The lethal yellow (AY/a) mouse has a defect in proopiomelanocortin (POMC) signaling in the brain that leads to obesity, and is resistant to the anorexigenic effects of the hormone leptin. It has been proposed that the weight-reducing effects of leptin are thus transmitted primarily by way of POMC neurons. However, the central effects of defective POMC signaling, and the absence of leptin, on weight gain in double-mutant lethal yellow (AY/a) leptin-deficient (lepob/lepob) mice were shown to be independent and additive. Furthermore, deletion of the leptin gene restored leptin sensitivity to AY/a mice. This result implies that in the AY/a mouse, obesity is independent of leptin action, and resistance to leptin results from desensitization of leptin signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boston, B A -- Blaydon, K M -- Varnerin, J -- Cone, R D -- DK/AR517330/DK/NIDDK NIH HHS/ -- DK02404/DK/NIDDK NIH HHS/ -- HD33703/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1641-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97201, USA. Laboratories, Rahway, NJ 07065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374468" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenalectomy
;
Agouti Signaling Protein
;
Alleles
;
Animals
;
Arcuate Nucleus of Hypothalamus/*metabolism
;
Blood Glucose/analysis
;
Corticosterone/blood
;
Crosses, Genetic
;
Eating/drug effects
;
Energy Metabolism
;
Female
;
Homeostasis
;
Insulin/blood
;
*Intercellular Signaling Peptides and Proteins
;
Leptin
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Obese
;
Neurons/metabolism
;
Obesity/genetics/*metabolism
;
Pro-Opiomelanocortin/*metabolism
;
Proteins/genetics/*metabolism/pharmacology
;
Signal Transduction
;
Weight Gain
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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