Publication Date:
2015-08-08
Description:
In physiological fluids and seawater, adhesion of synthetic polymers to solid surfaces is severely limited by high salt, pH, and hydration, yet these conditions have not deterred the evolution of effective adhesion by mussels. Mussel foot proteins provide insights about adhesive adaptations: Notably, the abundance and proximity of catecholic Dopa (3,4-dihydroxyphenylalanine) and lysine residues hint at a synergistic interplay in adhesion. Certain siderophores-bacterial iron chelators-consist of paired catechol and lysine functionalities, thereby providing a convenient experimental platform to explore molecular synergies in bioadhesion. These siderophores and synthetic analogs exhibit robust adhesion energies (E(ad) 〉/=-15 millijoules per square meter) to mica in saline pH 3.5 to 7.5 and resist oxidation. The adjacent catechol-lysine placement provides a "one-two punch," whereby lysine evicts hydrated cations from the mineral surface, allowing catechol binding to underlying oxides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maier, Greg P -- Rapp, Michael V -- Waite, J Herbert -- Israelachvili, Jacob N -- Butler, Alison -- New York, N.Y. -- Science. 2015 Aug 7;349(6248):628-32. doi: 10.1126/science.aab0556.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. ; Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA. ; Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. herbert.waite@lifesci.ucsb.edu jacob@engineering.ucsb.edu butler@chem.ucsb.edu. ; Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA. Materials Department, University of California, Santa Barbara, CA 93106, USA. herbert.waite@lifesci.ucsb.edu jacob@engineering.ucsb.edu butler@chem.ucsb.edu. ; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. herbert.waite@lifesci.ucsb.edu jacob@engineering.ucsb.edu butler@chem.ucsb.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26250681" target="_blank"〉PubMed〈/a〉
Keywords:
Adhesiveness
;
Adhesives/*chemistry
;
Aluminum Silicates/chemistry
;
Catechols/*chemistry
;
Dihydroxyphenylalanine/*chemistry
;
Hydrogen-Ion Concentration
;
Lysine/*chemistry
;
Molecular Mimicry
;
Oxidation-Reduction
;
Proteins/*chemistry
;
Siderophores/*chemistry
;
Titanium/chemistry
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
