Publication Date:
1991-04-19
Description:
Inositol 1,4,5-trisphosphate (IP3)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP3-induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP3-induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP3-induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP3-induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP3-induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finch, E A -- Turner, T J -- Goldin, S M -- GM35423/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Apr 19;252(5004):443-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2017683" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/pharmacology
;
Animals
;
Brain/ultrastructure
;
Calcimycin/pharmacology
;
Calcium/*metabolism/pharmacology
;
Calcium Radioisotopes
;
Cytosol/metabolism
;
Drug Synergism
;
Heparin/pharmacology
;
Inositol 1,4,5-Trisphosphate/*pharmacology
;
Kinetics
;
Magnesium/pharmacology
;
Microsomes/drug effects/metabolism
;
Rats
;
Synaptosomes/ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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