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  • 1
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    Chance and statistical significance in protein and DNA sequence analysis (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-07-03
    Description: Statistical approaches help in the determination of significant configurations in protein and nucleic acid sequence data. Three recent statistical methods are discussed: (i) score-based sequence analysis that provides a means for characterizing anomalies in local sequence text and for evaluating sequence comparisons; (ii) quantile distributions of amino acid usage that reveal general compositional biases in proteins and evolutionary relations; and (iii) r-scan statistics that can be applied to the analysis of spacings of sequence markers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karlin, S -- Brendel, V -- GM10452-29/GM/NIGMS NIH HHS/ -- HG00335-04/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 1992 Jul 3;257(5066):39-49.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Mathematics, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1621093" target="_blank"〉PubMed〈/a〉
    Keywords: *Amino Acid Sequence ; Animals ; Bacillus subtilis/genetics ; *Base Sequence ; DNA/chemistry/*genetics ; Drosophila/genetics ; Escherichia coli/genetics ; Humans ; Mathematics ; *Models, Genetic ; *Models, Statistical ; Proteins/chemistry/*genetics ; Saccharomyces cerevisiae/genetics ; Viruses/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Patchiness and correlations in DNA sequences (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-01-29
    Description: The highly nonrandom character of genomic DNA can confound attempts at modeling DNA sequence variation by standard stochastic processes (including random walk or fractal models). In particular, the mosaic character of DNA consisting of patches of different composition can fully account for apparent long-range correlations in DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karlin, S -- Brendel, V -- GM10452-29/GM/NIGMS NIH HHS/ -- HG00335-04/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 1993 Jan 29;259(5095):677-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Mathematics, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8430316" target="_blank"〉PubMed〈/a〉
    Keywords: Analysis of Variance ; Bacteriophage lambda/genetics ; Base Composition ; *Base Sequence ; DNA/*genetics ; Globins/genetics ; Humans ; Mathematics ; Models, Theoretical ; Plants, Toxic ; Stochastic Processes ; Tobacco/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Global convergence properties in multilocus viability selection models: the additive model and the Hardy-Weinberg law (1990)
    Springer
    Journal of mathematical biology 29 (1990), S. 161-176 
    Details
    ISSN: 1432-1416
    Keywords: Multilocus ; Additive selection ; Hardy-Weinberg polymorphism ; Global stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A natural coordinate system is introduced for the analysis of the global stability of the Hardy-Weinberg (HW) polymorphism under the general multilocus additive viability model. A global convergence criterion is developed and used to prove that the HW polymorphism is globally stable when each of the loci is diallelic, provided the loci are overdominant and the multilocus recombination is positive. As a corollary the multilocus Hardy-Weinberg law for neutral selection is derived.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168176
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