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  • Books  (29)
  • R5-920  (21)
  • ASTROPHYSICS
  • Chemistry
  • SPACE VEHICLES
  • STRUCTURAL MECHANICS
  • 1
    Keywords: Chemistry ; Chemistry ; Mathematics ; Computer simulation ; Computer software ; Weights and measures
    ISBN: 9781402069451
    Language: English
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  • 2
    Unknown
    Boston, MA : Springer
    Keywords: Chemistry ; Food science
    ISBN: 9780387251202
    Language: English
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  • 3
    Keywords: Biology ; Data processing ; Chemistry ; Chemistry, Physical organic ; Materials ; Nanotechnology
    ISBN: 9781402081897
    Language: English
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  • 4
    Keywords: Chemistry ; Chemistry, Physical organic ; Food science
    ISBN: 9780387752846
    Language: English
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  • 5
    Unknown
    Dordrecht : Springer
    Keywords: Chemistry ; Chemistry ; Mathematics ; Computer graphics ; Nanotechnology
    ISBN: 9781402060205
    Language: English
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  • 6
    Unknown
    Boston, MA : Springer
    Keywords: Chemistry ; Food science ; Nutrition
    Edition: Third Edition
    ISBN: 9780387288130
    Language: English
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  • 7
    Unknown
    Berlin, Heidelberg : Springer
    Keywords: Biomedical engineering ; Chemistry ; Chemistry, Physical organic ; Plasma (Ionized gases) ; Spectrum analysis
    ISBN: 9783540680383
    Language: English
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  • 8
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Signaling through the cell surface antigen receptor is a hallmark of various stages of lymphocyte development and adaptive immunity. Besides the adaptive immune system, the innate immunity is equally important for protection. However, the mechanistic connection between signaling, chromatin changes and downstream transcriptional pathways in both innate and adaptive immune system remains incompletely understood in hematopoiesis. A related issue is how the enhancers communicate to the promoters in a stage specific fashion and in the context of chromatin. Because the factors that regulate chromatin are generally present and active in most cell types, how could cell type and/or stage specific chromatin architecture is achieved in response to a particular immune signal?The genetic loci that encode lymphocyte cell surface receptors are in an "unrearranged” or “germline” configuration during the early stages of development. Thus, in addition to expressing lineage and/or stage specific transcription factors during each developmental stage, lymphocytes also need to rearrange their cognate receptor loci in a strictly ordered fashion. Hence, there must be a tightly coordinated communication between the recombination machinery and the transcriptional machinery (including chromatin regulators) at every developmental step. Mature B cells also undergo classswitch recombination and somatic hypermutation. Importantly, along the way, these cells must avoid autoimmune responses and only those cells capable of recognizing foreignantigens are preserved to reach peripheral organs where they must function. The exquisite regulation that govern chromatin accessibility, recombination and transcription regulation in response to the environmental signals in the immune system is discussed here is a series of articles.
    Keywords: R5-920 ; RC581-607 ; Promoter ; Chromatin ; transcription ; Enhancer ; immune response ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
    Publication Date: 2023-12-21
    Description: Natural products are increasingly attracting attention from both basic and applied science. Plant secondary metabolites, especially alkaloids, are receiving interest from a wide range of researchers due to their biological activity. They are produced to protect plants from diseases and herbivores. Therefore, they reveal a toxic activity that affects organisms at various levels of biological organization. A growing amount of research is proving their antimicrobial, antifungal, insecticidal, and anticancer activities. That makes them applicable in various fields from medicine, to pharmacology, veterinary, and toxicology, to crop protection. This Special Issue of Toxins, “Biological Activities of Alkaloids: From Toxicology to Pharmacology"", collects 15 manuscripts describing the ecological, biological, pharmacological, and toxicological effects as well as structural and analytical aspects of plant alkaloids, their mode of action, and possible application in veterinary, medicine, and plant protection. These studies prove the potential for alkaloid application in various areas of science.
    Keywords: R5-920 ; RM1-950 ; leukemia ; n/a ; biodistribution ; glycoalkaloids ; insect heart ; Solanum melongena L. ; antibacterial ; alkaloid ; ?-carboline ; Ovarian cancer ; Chelidonium majus ; secondary metabolites ; lindoldhamine ; livestock ; insect ; chanoclavine ; bisbenzylisoquinoline alkaloid ; cytotoxic activity ; Staphylococcus aureus ; antioxidant ; acid-sensing ion channel subtype 1a ; malonylated form ; HPLC-DAD ; ergot alkaloids ; nociception ; macrophage ; Arecoline ; Macleaya cordata ; antifungal ; neuropathic pain ; Corydalis lutea ; antiviral ; Curine ; lung cancer cells ; lipopolysaccharide ; Epichloë ; Meconopsis cambrica ; Berberis thunbergii ; SRC ; Dicentra spectabilis ; apoptosis ; endophyte ; natural sources ; dehydrocrenatidine ; neutrophil ; EGFR ; anticancer ; solamargine ; berberine ; isoquinoline alkaloids ; natural products ; Radix Aconiti Lateralis preparations ; short-term and long-term usage ; inflammation ; acute toxicity ; Mahonia aquifolia ; Palmatine ; sanguinarine ; Rutidea parviflora ; voltage-gated sodium channels ; cytotoxicity ; toxicology ; malonyl-solamargine ; alkaloids ; acetylcholinesterase ; beetles ; Fumaria officinalis ; antimicrobial activity ; solasonine ; FAK ; plant secondary metabolites ; di-ester diterpenoid alkaloids ; mAchR3 ; subchronic feeding study ; mono-ester diterpenoid alkaloids ; Tenebrio molitor ; Apoptosis ; reproduction ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
    Publication Date: 2023-12-21
    Description: Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout.
    Keywords: R5-920 ; RC648-665 ; bone ; bic Book Industry Communication::M Medicine
    Language: English
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