ALBERT

Description: This study examined the association between local insulin-like growth factor I (IGF-I) overexpression and atrophy in skeletal muscle. We hypothesized that endogenous skeletal muscle IGF-I mRNA expression would decrease with hindlimb unloading (HU) in mice, and that transgenic mice overexpressing human IGF-I (hIGF-I) specifically in skeletal muscle would exhibit less atrophy after HU. Male transgenic mice and nontransgenic mice from the parent strain (FVB) were divided into four groups (n = 10/group): 1) transgenic, weight-bearing (IGF-I/WB); 2) transgenic, hindlimb unloaded (IGF-I/HU); 3) nontransgenic, weight-bearing (FVB/WB); and 4) nontransgenic, hindlimb unloaded (FVB/HU). HU groups were hindlimb unloaded for 14 days. Body mass was reduced (P 〈 0.05) after HU in both IGF-I (-9%) and FVB mice (-13%). Contrary to our hypothesis, we found that the relative abundance of mRNA for the endogenous rodent IGF-I (rIGF-I) was unaltered by HU in the gastrocnemius (GAST) muscle of wild-type FVB mice. High-level expression of hIGF-I peptide and mRNA was confirmed in the GAST and tibialis anterior (TA) muscles of the transgenic mice. Nevertheless, masses of the GAST and TA muscles were reduced (P 〈 0.05) in both FVB/HU and IGF-I/HU groups compared with FVB/WB and IGF-I/WB groups, respectively, and the percent atrophy in mass of these muscles did not differ between FVB and IGF-I mice. Therefore, skeletal muscle atrophy may not be associated with a reduction of endogenous rIGF-I mRNA level in 14-day HU mice. We conclude that high local expression of hIGF-I mRNA and peptide in skeletal muscle alone cannot attenuate unloading-induced atrophy of fast-twitch muscle in mice.

Description: The relative response of the five segments of the HEAO 3 gamma-ray-spectroscope anticoincidence shield (a 6.62-cm-thick 33.1-cm-OD 27.4-cm-high CsI cylinder) is used to estimate the directions of gamma-ray bursts on February 13, 1980 and September 29, 1979. The operation of the instrument and the data-analysis procedures are described, and the results are presented graphically. The 1980 event is located in an error box centered on alpha = 104.5 deg and delta = -15 deg (error box A of Atteia et al., 1987). The position of the 1979 event (alpha = 75 deg and delta = 40 deg) is shown to be consistent with ISEE 3 and Pioneer Venus Orbiter arrival times.

Description: From long-slit spectrophotometry of the bipolar nebula associated with the unusual OH source, OH 0739 - 14, the presence of a blue companion to the M9 III central star was shown and a Herbig-Haro-like knot beyond each nebular lobe was discovered. From differential colors of the lobes and from radial velocities of these knots it was demonstrated that the system inclines its northern lobe in the forward direction. It was also shown that the nebulous knots are shocks being driven into an extensive circumstellar envelope, and that this material is very overabundant in nitrogen, suggesting that it is matter lost from a star of mass greater than 3 solar masses. A model of biconical ejection from a central binary is consistent with the OH observations, and a possible relation of OH 0739 - 14 to the symbiotic stars and to bipolar planetary nebulae is suggested.

Description: A brief description of the nature of Herbig-Haro nebulae is given, and the shock-wave origin of the nebulae is discussed. Kinematical evidence suggests that Herbig-Haro objects are ejected in bipolar flows from young stars. Evidence from infrared observations of the stars that excite Herbig-Haro objects is summarized; these stars appear to be T Tauri stars. The origin of these nebulae is discussed emphasizing energy required to power them, and a number of questions are posed pertaining to outflow mechanisms associated with the exciting stars.

Description: Kuiper Airborne Observatory observations of several resolved far-infrared structures that are likely to represent disks formed during the process of the collapse of a cloud to form a star are discussed. An infrared radiation nebula, star HH57, and SVS13 were studied. Forty seven and 95 micron maps of far infrared radiation are given.

Description: IUE short wavelength spectra are presented for the low excitation Herbig-Haro objects HH 43 and HH 47. In the former, several emission lines in the Lyman band of H2 from an excited state are observed which are due to fluorescence from the H Ly-alpha line pumping a lower state (that is in turn excited by a low-velocity shock wave). No evidence of highly ionized gas emission is found in the UV spectra, and both objects exhibit a UV continuum which peaks in the vicinity of 1500 A and is probably caused by H two-photon emission enhanced by low velocity shock collisional excitation.

Description: Accurate astrometry and infrared photometry are presented for 16 objects that are believed to represent the exciting stars for Herbig-Haro (HH) objects in their vicinities. These identifications are made on the bases of steeply rising energy distributions, proper motions of HH objects, alignment of sources with HH objects, or far-infrared emission. Exciting stars for the following HH objects are newly discovered or recognized: HH 17; HH 31; HH 32; HH 33 and 40; HH 34; HH 38 and 43; HH group 14 in NGC 2264; RNO 40; RNO 43; and GGD 33a, 33b, and 35. Geometrical alignments of some sources with HH objects support the view that young stars are capable of channeling kinetic energy into small solid angles, as does the fact that some sources are slightly displaced from the apices of fan nebulae (HH 17, R Mon, Haro 6-10). These exciting stars span a wide range of bolometric luminosity, although all are likely to be very young.

Description: New ultraviolet and optical observations of Herbig-Haro object No. 43 are reported. Continuum and emission-line fluxes in the wavelength range 1250 to 7350 A have been measured. The continuum fluxes are best matched by an enhanced H exp 0 two-photon component added to H free-bound emission, assuming a Theta Ori extinction curve with E(B - V) = 0.2, R = 5. The structure and dynamics of three components within the object are discussed. The object has a radiative output of not less than 0.23 solar luminosities in ultraviolet and optical radiation combined. The energy requirements are discussed in terms of the production of shock waves by a collimated, supersonic mass outflow from a nearby infrared source.

Description: The photodesorption of molecules and atoms from the surfaces of interstellar grains can be an important source of heating for the interstellar medium and the origin of instabilities which may separate grains and gas. For low densities, the force exerted on the grains is proportional to the gas density and independent of the radiation intensity; for high densities, it is proportional to the radiative flux and independent of the gas density. This force may act differently on grains of different sizes. The photoelectric effect may also be an efficient mechanism for the separation of gas and dust in diffuse clouds.

Description: Far-infrared (40-160 micron) observations of Herbig-Haro objects and their probable exciting stars are presented. The importance of these far-infrared observations is epitomized by the fact that, on average, 70 percent of the bolometric luminosity of a typical candidate star is radiated beyond the longest detected ground-based wavelength, even for those objects observed out to 20 micron from the ground. Extended far-infrared emission characterizes some of these regions. Some Herbig-Haro nebulae are themselves conspicuous 100 micron peaks (e.g., HH 1 and HH 25). A bipolar structure is found at 100 micron in the vicinity of the Cohen-Schwartz star. All the exciting stars must be low-mass objects (approximately less than 3 solar mass). It is argued that they might be approximately 1 solar mass protostars still in their accretion phase.