ISSN:
1432-0983
Keywords:
Key words Heat-shock response
;
Multidrug resistance
;
AP-1 homolog
;
Saccharomyces cerevisiae
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract We have examined whether the stress-induced transcriptional activation of YDR1/PDR5/STS1 is mediated by yAP-1 and yAP-2. Of the stresses examined, heat shock-induced, rapid and transient PDR5 expression became very low in a yap1 yap2 double-gene disruptant, indicating that the yAP proteins mediate the response. Similar results were obtained with SNQ2, a close homologue of PDR5. A set of 5′-truncation derivatives of the PDR5 gene identified the region from –484 to –434 as being sufficient for the response. A sequence similar to the yAP-1 recognition element recently identified in the stress-responsive yeast genes was found in this region and in the 5′-flanking sequences of SNQ2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002940050023
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