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  • Chemistry  (16)
  • Animals  (3)
  • AIRCRAFT DESIGN, TESTING AND PERFORMANCE  (2)
  • Electron microscopy  (2)
  • Ground Support Systems and Facilities (Space)  (2)
  • Lorenz relation  (2)
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  • 21
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    Unknown
    A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-11
    Description: A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus. The compound has 300 to 400 times the affinity for pancreatic, ileal, and gallbladder CCK receptors than proglumide, a standard agent of this class. Moreover, asperlicin is highly selective for peripheral CCK receptors relative to brain CCK and gastrin receptors. Since asperlicin also exhibits long-lasting CCK antagonist activity in vivo, it should provide a valuable tool for investigating the physiological and pharmacological actions of CCK.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, R S -- Lotti, V J -- Monaghan, R L -- Birnbaum, J -- Stapley, E O -- Goetz, M A -- Albers-Schonberg, G -- Patchett, A A -- Liesch, J M -- Hensens, O D -- New York, N.Y. -- Science. 1985 Oct 11;230(4722):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2994227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aspergillus/*metabolism ; Benzodiazepinones/*isolation & purification/pharmacology ; Chemical Phenomena ; Chemistry ; Cholecystokinin/*antagonists & inhibitors/pharmacology/physiology ; Dose-Response Relationship, Drug ; Gallbladder/drug effects ; Guinea Pigs ; Ileum/drug effects ; Pancreas/drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Receptors, Cholecystokinin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 22
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    Plasticity of hippocampal circuitry in Alzheimer's disease (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-06
    Description: Two markers of neuronal plasticity were used to compare the response of the human central nervous system to neuronal loss resulting from Alzheimer's disease with the response of rats to a similar neuronal loss induced by lesions. In rats that had received lesions of the entorhinal cortex, axon sprouting of commissural and associational fibers into the denervated molecular layer of the dentate gyrus was paralleled by a spread in the distribution of tritiated kainic acid-binding sites. A similar expansion of kainic acid receptor distribution was observed in hippocampal samples obtained postmortem from patients with Alzheimer's disease. An enhancement of acetylcholinesterase activity in the dentate gyrus molecular layer, indicative of septal afferent sprouting, was also observed in those patients with a minimal loss of cholinergic neurons. These results are evidence that the central nervous system is capable of a plastic response in Alzheimer's disease. Adaptive growth responses occur along with the degenerative events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geddes, J W -- Monaghan, D T -- Cotman, C W -- Lott, I T -- Kim, R C -- Chui, H C -- AG00538/AG/NIA NIH HHS/ -- MH 19691/MH/NIMH NIH HHS/ -- P50AG5142/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1179-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071042" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholinesterase/metabolism ; Alzheimer Disease/*pathology ; Animals ; Hippocampus/enzymology/*pathology ; Humans ; Kainic Acid/metabolism ; Male ; *Neuronal Plasticity ; Neurons/pathology ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 23
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    Description of the HiMAT Tailored composite structure and laboratory measured vehicle shape under load (1981)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The aeroelastically tailored outer wing and canard of the highly maneuverable aircraft technology (HiMAT) vehicle are closely examined and a general description of the overall structure of the vehicle is provided. Test data in the form of laboratory measured twist under load and predicted twist from the HiMAT NASTRAN structural design program are compared. The results of this comparison indicate that the measured twist is generally less than the NASTRAN predicted twist. These discrepancies in twist predictions are attributed, at least in part, to the inability of current analytical composite materials programs to provide sufficiently accurate properties of matrix dominated laminates for input into structural programs such as NASTRAN.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: NASA-TM-81354 , H-1144
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 24
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    Allocating SMART Reliability and Maintainability Goals to NASA Ground Systems (2013)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: This paper will describe the methodology used to allocate Reliability and Maintainability (R&M) goals to Ground Systems Development and Operations (GSDO) subsystems currently being designed or upgraded.
    Keywords: Ground Support Systems and Facilities (Space)
    Type: KSC-2012-109 , Reliability and Maintainability Symposium; Jan 28, 2013 - Jan 31, 2013; Orlando, FL; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 25
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    Development of Hybrid Product Breakdown Structure for NASA Ground Systems (2013)
    In:  CASI
    Details
    Publication Date: 2019-07-27
    Description: The Product Breakdown Structure is traditionally a method of identification of the products of a project in a tree structure. It is a tool used to assess, plan, document, and display the equipment requirements for a project. It is part of a product based planning technique, and attempts to break down all components of a project in as much detail as possible, so that nothing is overlooked. The PBS for ground systems at the Kennedy Space Center is being developed to encompass the traditional requirements including the alignment of facility, systems, and components to the organizational hierarchy. The Ground Operations Product Breakdown Structure is a hybrid in nature in that some aspects of a work breakdown structure will be incorporated and merged with the Architecture Concept of Operations, Master Subsystem List, customer interface, and assigned management responsibility. The Ground Operations Product Breakdown Structure needs to be able to identify the flexibility of support differing customers (internal and external) usage of ground support equipment within the Kennedy Space Center launch and processing complex. The development of the Product Breakdown Structure is an iterative activity Initially documenting the organization hierarchy structure and relationships. The Product Breakdown Structure identifies the linkage between the customer program requirements, allocation of system resources, development of design goals, and identification logistics products. As the Product Breakdown Structure progresses the incorporation of the results of requirement planning for the customer occurs identifying facility needs and systems. The mature Product Breakdown Structure is baselined with a hierarchical drawing, the Product Breakdown Structure database, and an associated document identifying the verification of the data through the life cycle of the program/product line. This paper will document, demonstrate, and identify key aspects of the life cycle of a Hybrid Product Breakdown Structure. The purpose is to show how a project management and system engineering approach can be utilized for providing flexible customer service in an evolving manned space flight launch processing environment.
    Keywords: Ground Support Systems and Facilities (Space)
    Type: KSC-2013-258R , KSC-2012-279 , AIAA 2013 Space Conference and Exposition; 10-12, Sep. 2013; San Diego, CA; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 26
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    AD-1 oblique wing aircraft program (1980)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The oblique wing concept for super- and subsonic transport was assessed by analysis and wind tunnel radio control model and remotely piloted vehicle testing. A one-sixth scale wind tunnel model and a low speed manned oblique wing research airplane (AD-1) were developed. Model wind tunnel test data on dynamic structural response characteristics were used in a simulator to develop the control system. The airplane is of simple design with fiber glass skin, weight of approximately 2100 lbs and speeds of up to 175 knots at altitudes up to 15,000 ft. Flight testing will investigate handling and flying qualities, oblique wing flight control characteristics, aeroelastic wing design and will compare actual with predicted aerodynamic characteristics. Nineteen flights were made at 12,000 to 13,000 feet with speeds of 100-160 knots. Flutter clearance as a function of wing sweep angle is now under investigation.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: SAE PAPER 801180 , Aerospace Congress and Exposition; Oct 13, 1980 - Oct 16, 1980; Los Angeles, CA
    Format: text
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