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  • 1
    ISSN: 1573-501X
    Keywords: Solid-phase synthesis ; Polymer supports ; Linkers ; Automated organic synthesis ; Combinatorial chemistry ; Chemical synthesis development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such asArgoGel ™ (PS-PEG-based) andArgo-X203 (PS-based); and (ii) theNautilus ™ 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-06-28
    Description: Deep-space telecommunications systems will eventually operate at visible or near-infrared regions to provide increased information return from interplanetary spacecraft. This would require an onboard laser transponder in place of (or in addition to) the usual microwave transponder, as well as a network of ground-based and/or space-based optical observing stations. This article examines the expected navigation systems to meet these requirements. Special emphasis is given to optical astrometric (angular) measurements of stars, solar system target bodies, and (when available) laser-bearing spacecraft, since these observations can potentially provide the locations of both spacecraft and target bodies. The role of astrometry in the navigation system and the development options for astrometric observing systems are also discussed.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Type: The Telecommunications and Data Acquisition; p 23-40
    Format: application/pdf
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