ISSN:
1573-501X
Keywords:
Solid-phase synthesis
;
Polymer supports
;
Linkers
;
Automated organic synthesis
;
Combinatorial chemistry
;
Chemical synthesis development
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such asArgoGel ™ (PS-PEG-based) andArgo-X203 (PS-based); and (ii) theNautilus ™ 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01715635
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