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  • 1
    ISSN: 1573-501X
    Keywords: Solid-phase synthesis ; Polymer supports ; Linkers ; Automated organic synthesis ; Combinatorial chemistry ; Chemical synthesis development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following: (i) new solid supports such asArgoGel ™ (PS-PEG-based) andArgo-X203 (PS-based); and (ii) theNautilus ™ 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-08-31
    Description: On February 14, 2000, an orbit insertion burn will place NASA's Near Earth Asteroid Rendezvous (NEAR) spacecraft (S/C) into orbit around asteroid 433 Eros. NEAR will initially orbit Eros with distances ranging from 500 to 100 km in order to characterize the shape, gravity and spin of Eros. Once the physical parameters of Eros are determined reasonably well, the plan is to establish an orbit of the NEAR S/C with increasingly lower altitudes as the one year orbital mission progresses while further characterizing the gravity and shape of Eros. Towards the end of the NEAR mission, after the shape, gravity and spin of Eros have been well characterized, the scientific interest of obtaining very close observations (〈 5 km) can be realized. The navigation during this phase relies on a combination of NASA's Deep Space Network (DSN) radio metric tracking, laser ranging (LIDAR) data from the S/C to the surface of Eros, and onboard optical imaging of landmarks on Eros. This paper will provide preliminary plans for mission design and navigation during the last two months of the orbit phase, where several close passes to the surface will be incorporated to enhance the science return. The culmination of these close passes will result in the eventual landing of the S/C on the surface of Eros. Several considerations for these plans are given by Antreasian, et at. [1998]. The objective for the end of the mission will be to land the S/C autonomously using the surface relative information obtained from the onboard LIDAR instrument. The goal will be to soft land the S/C in such a way as to keep it operational. With the use of an onboard LIDAR landing algorithm as discussed by Antreasian et at. [1998], it is believed that the S/C impact velocity can be kept well under 7 m/s which is a requirement for allowing the S/C to remain operational.
    Keywords: Astronautics (General)
    Format: application/pdf
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  • 3
    Publication Date: 2019-06-28
    Description: Deep-space telecommunications systems will eventually operate at visible or near-infrared regions to provide increased information return from interplanetary spacecraft. This would require an onboard laser transponder in place of (or in addition to) the usual microwave transponder, as well as a network of ground-based and/or space-based optical observing stations. This article examines the expected navigation systems to meet these requirements. Special emphasis is given to optical astrometric (angular) measurements of stars, solar system target bodies, and (when available) laser-bearing spacecraft, since these observations can potentially provide the locations of both spacecraft and target bodies. The role of astrometry in the navigation system and the development options for astrometric observing systems are also discussed.
    Keywords: AIRCRAFT COMMUNICATIONS AND NAVIGATION
    Type: The Telecommunications and Data Acquisition; p 23-40
    Format: application/pdf
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