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  • 1
    Electronic Resource
    Electronic Resource
    Disparity between clinical and immune responses in a controlled trial of azathioprine in rheumatoid arthritis (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 405-410 
    Details
    ISSN: 1432-1041
    Keywords: Rheumatoid arthritis ; immunosuppressive therapy ; azathioprine ; controlled trial ; clinical autoimmune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Drugs that interfere with the immune responsein vitro, such as azathioprine (AZ), have been used extensively since 1964 in clinical therapeutic trials of autoimmune diseases. However, few adequately controlled studies are available concerning the concurrent effect of AZ on the immune and clinical responses to treatment of rheumatoid arthritis (RA). Thirty patients suffering from classical seropositive RA received AZ (1.5 – 2.0 mg/kg/day) and placebo in a controlled clinical cross-over study for two 12-week periods. Other treatments were kept constant throughout the entire 6 months. In terms of the clinical responses of joint count and grip strength patients receiving AZ improved markedly, in contrast to the placebo group. After 2 months, joint scanning revealed no progress of the disease in patients undergoing AZ treatment. Corresponding with the remarkably beneficial clinical effect of AZ, a significant drop in immunoglobulins was observed. However, since AZ failed to suppressin vivo specific antibody synthesis in RA, the question remains as to whether this drug actually does interfere with the autoimmunogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606556
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  • 2
    Electronic Resource
    Electronic Resource
    Emulsion copolymerization of styrene with monomeric emulsifiers (1995)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 6 (1995), S. 452-454 
    Details
    ISSN: 1042-7147
    Keywords: emulsion polymerization ; AIBN ; monomeric emulsifiers ; latex characterization ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Monomeric emulsifiers with different copolymerization reactivities were used as stabilizers in emulsion polymerization of styrene initiated by 2,2′ azobisisobutyronitrile (AIBN). A significant change in emulsifier function was observed between equal micellar concentrations of surface-active sodium sulfopropyl alkyl maleates and the corresponding sodium sulfopropyl dodecyl fumarate. In the presence of less reactive maleates, copolymerization mainly occurs in the interface of the monomer swollen particles, while copolymerization with the fumarate in the first period of emulsion polymerization leads to polyelectrolyte formation in the water phase.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1995.220060705
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