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  • 1
    Electronic Resource
    Electronic Resource
    The effects of chronic carbamazepine treatment on haem biosynthesis in man and rat (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 241-247 
    Details
    ISSN: 1432-1041
    Keywords: carbamazepine ; porphyria ; epilepsy ; haem biosynthesis ; enzyme induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The anticonvulsant drug carbamazepine has been reported to produce a condition clinically and biochemically similar to acute intermittent porphyria (AIP). We have determined the effect of chronic carbamazepine treatment on the activities of the enzymes of haem biosynthesis in circulating blood cells and on the urinary excretion of porphyrins and their precursors in 53 epileptic patients receiving monotherapy and in 42 age- and sex-matched controls. In the patients the mean activity of leucocyte 5-aminolaevulinic acid (ALA) synthase, the rate-limiting enzyme of the pathway, was 218% of control values (p〈0.001) and ALA-dehydratase activity was reduced by 37% (p〈0.001). Circulating carbamazepine concentrations correlated negatively with ALA dehydratase (r s=−0.45;p〈0.01). Porphobilinogen deaminase and uroporphyrinogen decarboxylase appeared unaffected by carbamazepine treatment. Significant quantitative increases in the urinary excretion of porphobilinogen and total porphyrins (bothp〈0.05) accompanied the changes in enzyme activity. Similar dose-dependent effects on ALA synthase and ALA dehydratase were shown to occur in rats treated for 5 days with 3 different doses of carbamazepine. These findings further support the porphyrinogenicity of carbamazepine, but the pattern of enzyme alteration differs from that found in AIP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558260
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of industrial lead poisoning on cytochrome P450 mediated phenazone (antipyrine) hydroxylation (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 235-239 
    Details
    ISSN: 1432-1041
    Keywords: phenazone ; lead ; haem biosynthesis ; cytochrome P450 ; saliva
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a group of ten male adults admitted to hospital with clinical symptoms of lead exposure, phenazone elimination rates, blood δ-amino-laevulinic acid dehydratase (ALA.D) activity, blood lead levels and haemoglobin were measured. Investigations were carried out before, immediately after and again at least 12 weeks after cessation of CaEDTA (sodium calcium edetate) chelation therapy. Following chelation, phenazone elimination rates were increased as assessed by a decrease in half life and increase in clearance. This was significant, both immediately after and 12 weeks after cessation of chelation therapy. The change in rate of phenazone metabolism was associated with improved clinical status, with lowered blood lead levels and raised haemoglobin and ALA.D activity. The results of the study suggest that the depression in phenazone elimination in lead intoxication is possibly due to depressed hepatic cytochrome P450 levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609867
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    Paper (German National Licenses)
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  • 3
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    Forward velocity effects on fan noise and the suppression characteristics of advanced inlets as measured in the NASA Ames 40 by 80 foot wind tunnel: Acoustic data report (1981)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Forward velocity effects on the forward radiated fan noise and on the suppression characteristics of three advanced inlets relative to a baseline cylindrical inlet were measured in a wind tunnel. A modified JT15D turbofan engine in a quiet nacelle was the source of fan noise; the advanced inlets were a CTOL hybrid inlet, an STOL hybrid inlet, and a treated deflector inlet. Also measured were the static to flight effects on the baseline inlet noise and the effects on the fan noise of canting the baseline inlet 4 deg downward to simulate typical wing mounted turbofan engines. The 1/3 octave band noise data from these tests are given along with selected plots of 1/3 octave band spectra and directivity and full scale PNL directivities. The test facilities and data reduction techniques used are also described.
    Keywords: ACOUSTICS
    Type: NASA-CR-152329
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Acoustic characteristics of two hybrid inlets at forward speed (1980)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: A wind tunnel investigation of the acoustic and aerodynamic characteristics of two hybrid inlets installed on a JT15D-1 turbofan engine was performed. The hybrid inlets combined moderate throat Mach number and wall acoustic treatment to suppress the fan inlet noise. Acoustic and aerodynamic data were recorded over a range of flight and engine operating conditions. In a simulated flight environment, the hybrid inlets provided significant levels of suppression at both design and off-design throat Mach numbers with good aerodynamic performance. A comparison of inlet noise at quasi-static and forward-speed conditions in the wind tunnel showed a reduction in the fan tones, demonstrating the flight cleanup effect. High angles of attack produced slight increases in fan noise at the high acoustic directivity angles.
    Keywords: ACOUSTICS
    Type: AIAA PAPER 79-0678
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    Forward velocity effects on fan noise and the suppression characteristics of advanced inlets as measured in the NASA-Ames 40 by 80 foot wind tunnel (1980)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Forward velocity effects on the forward radiated fan noise and on the suppression characteristics of three advanced inlets relative to a baseline cylindrical inlet were measured in the NASA Ames Research Center 40 x 80 foot Wind Tunnel. A modified JT15D turbofan engine in a quiet nacelle was the source of fan noise; the advanced inlets were a Conventional Takeoff/Landing (CTOL) hybrid inlet, a Short Takeoff/Landing (STOL) hybrid inlet, and a treated deflector inlet. Also measured were the static to flight effects on the fan noise of canting the baseline inlet 4 deg downward to simulate typical wing mounted turbofan engines. The CTOL hybrid inlet suppressed the high tip speed fan noise as much as 18 PNdB on a 61 m (200 ft) sideline scaled to a CF6 size engine while the STOL hybrid inlet suppressed the low tip speed fan noise as much as 13 PNdB on a 61 m (200 ft) sideline scaled to a OCSEE size engine. The deflector inlet suppressed the high tip speed fan noise as much as 13 PNdB at 61 m (200 ft) overhead scaled to a CF6 size engine. No significant changes in fan noise suppression for the CTOL and STOL hybrid inlets occurred for forward velocity changes above 21 m/s (68 ft/s) or for angle of attack changes up to 15 deg. However, changes in both forward velocity and angle of attack changed the deflector inlet noise unpredictably due to the asymmetry of the inlet flow field into the fan.
    Keywords: ACOUSTICS
    Type: NASA-CR-152328 , NAS 1.26:152328 , R79AEG626
    Format: application/pdf
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  • 6
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    Evaluation of the in-flight noise signature of a 32-chute suppressor nozzle: Acoustic data report (1977)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Outdoor static and 40 x 80 FT wind tunnel tests of the J79-15 engine/nacelle system with the conic nozzle and 32-chute exhaust suppressor were conducted to acquire the data necessary to evaluate the simulated in-flight signature of an engine-size 32-chute exhaust nozzle suppressor using the 40 x 80 ft wind tunnel and to study possible engine core noise contamination of the jet signature. The tests are described and and a sampling of the data acquired is presented. Included are aero performance summaries, as-measured and composite 1/3 OBSPL spectra for the 70 ft sideline high and low mics from the outdoor static tests, sideline traverse spectra and internal noise measurements from both the outdoor static and the 40 x 80 ft wind tunnel tests.
    Keywords: ACOUSTICS
    Type: NASA-CR-152076
    Format: application/pdf
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  • 7
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    Distortion-rotor interaction noise produced by a drooped inlet (1980)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The 'drooped' inlet used on most wing mounted engines produces a wall static pressure distortion at the fan face of about plus or minus 2%. The interaction of the fan rotor with this fixed distortion pattern produces blade passing frequency and harmonic tone levels in flight which contribute to forward radiated engine noise spectra. Data from a wind tunnel test, using both a drooped inlet and an inlet with no droop, show large changes in forward radiated noise levels over a limited fan speed range. An analytical model of this fan noise mechanism is developed and is used to account for the major features of the measured results.
    Keywords: ACOUSTICS
    Type: AIAA PAPER 80-1050 , Aeroacoustics Conference; Jun 04, 1980 - Jun 06, 1980; Hartford, CT
    Format: text
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    NASA TECHNICAL REPORTS
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