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  • 75.30.Kz  (1)
  • monoclonal antibodies  (1)
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  • 1
    ISSN: 1090-6487
    Keywords: 62.65.+k ; 75.30.Kz ; 64.70.Kb ; 43.20.Hq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The temperature dependences of the transverse V t and longitudinal V l sound velocities in single crystals of the perovskites La1−x SrxMnO3 (x=0.1, 0.175, 0.2, 0.25) in the temperature interval T=70–350 K are investigated by the resonance method. Anomalies — small minima and kinks in the temperature dependences V l (T) and V t (T) — are observed at the Curie points. A strong jumplike increase (by up to 30%) in both the longitudinal and transverse sound velocities, which attests to sizable hardening of the acoustic branches of the phonon spectrum, is observed near the temperatures of the structural transitions between the rhombohedral and orthorhombic phases (for x=0.175, 0.2, 0.25) and at the phase transition to the polaron-ordered state (for x=0.1).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-8221
    Keywords: monoclonal antibodies ; digoxin ; Na, K-ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Effect of high-affinity mouse monoclonal antidigoxin antibodies D22 on digoxin-induced cardiac disturbances is studied in guinea pigs injected with 0.5 mg/kg digoxin. Five minutes after digoxin injection, bradycardia, isolated extrasystoles, conduction disturbances, and changes in theST segment andQRS complex appear; digoxin concentration attains 0.2–0.4 μg/ml. Antidigoxin monoclonal antibodies injected 10 min after digoxin slightly reduce heart rate, prevent isolated extrasystoles, improve atrioventricular conduction, and normalize the amplitude of theST segment and the shape of theQRS complex. Serum digoxin concentration decreases to 0.015–0.03 μg/ml. These data suggest that monoclonal antidigoxin antibodies can be effectively used in acute digoxin intoxication.
    Type of Medium: Electronic Resource
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