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  • 1
    Electronic Resource
    Electronic Resource
    Distribution of GABA-immunoreactive neurons in the forebrain of the goldfish, Carassius auratus (1990)
    Springer
    Cell & tissue research 260 (1990), S. 77-84 
    Details
    ISSN: 1432-0878
    Keywords: GABA ; Immunohistochemistry ; Chemical neuroanatomy ; Goldfish (Carassius auratus)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of gamma-aminobutyric acid (GABA) immunoreactivity was studied in the forebrain (tel-and diencephalon) of the goldfish by means of immunocytochemistry on Vibratome sections using antibodies against GABA. Positive perikarya were detected in the olfactory bulbs and in all divisions of the telencephalon, the highest density being found along the midline. In the diencephalon, GABA-containing cell bodies were found in the hypothalamus, in particular in the preoptic and tuberal regions. The inferior lobes, the nucleus recessus lateralis, and more laterodorsal regions, such as the nucleus glomerulosus and surrounding structures, also exhibited numerous GABA-positive perikarya. Cell bodies were also noted in the thalamus, in particular in the dorsomedial, dorsolateral and ventromedial nuclei. The relative density of immunoreactive fibers was evaluated for each brain nucleus and classified into five categories. This ubiquitous distribution indicates that, as in higher vertebrates, GABA most probably represents one of the major neurotransmitters in the brain of teleosts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297492
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacological model of catecholamine depletion in the hypothalamus of fetal and neonatal rats and its application (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 617-624 
    Details
    ISSN: 1573-6830
    Keywords: catecholamines ; hypothalamus ; development ; uptake ; α-methyl-m-tyrosine ; 6-hydroxydopamine ; HPLC ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The present study aimed to develop a pharmacological model of catecholamine (CA) depletion in the hypothalamus during the period of its morphofunctional development, i.e. in fetal and neonatal rats of both sexes. 2. In the first series of experiments, pregnant females and, hence, fetuses were systemically treated daily from the embryonic day (E) 13 to E20 with the inhibitor of the CA synthesis α-methyl-m-tyrosine. The CA concentrations were subsequently measured in the fetal hypothalamus at E21 by high performance liquid chromatography with electrochemical detection (HPLC-ED). In the second series of experiments, neonatal rats were injected with neurotoxin, 6-hydroxydopamine and/or α-methyl-m-tyrosine daily from the 2nd postnatal day (P2) to P10. 3. The HPLC-ED assay of hypothalamic catecholamines (CA's) at E21 and P11 showed that both in fetuses and neonates, α-methyl-m-tyrosine caused more than 50% depletion of hypothalamic noradrenaline and adrenaline, while the dopamine (DA) level remained unchanged. The combined treatment of neonatal rats with α-methyl-m-tyrosine and 6-hydroxydopamine resulted additionally in a 25% decreased level of DA. 4. The influence of CA deficiency on the developing hypothalamic CA system was further evaluated by measuring [3H]DA uptake by nervous tissuein vitro. 5. The CA deficiency caused a 50% drop of [3H]DA uptake by the hypothalamic tissue in treated fetuses suggesting a stimulating effect of CA's on the early development of the CA system. In pharmacologically treated neonatal rats [3H]DA uptake remained at the control level showing no influence of the CA deficiency on the developing CA system after birth. 6. The usefulness of the proposed pharmacological model for studying of CA influence on differentiating hypothalamic target neurons is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151900
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