ISSN:
1432-1041
Keywords:
Tricyclic antidepressants
;
drug metabolism
;
antipyrine
;
6β-hydroxycortisol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Plasma antipyrine half-lives were measured in thirty adult subjects before and after 7 and 28 days treatment with one of five tricyclic antidepressants. Overall, considering the five antidepressants together, there was a small but significant reduction in half-life after both periods of treatment. In four subjects studied, increased urinary output of 6β-hydroxycortisol following chronic nortriptyline treatment provides further evidence of a stimulatory effect of tricyclic antidepressant on drug metabolism. In a separate study, the induction effect of tricyclic antidepressants was found to be much less marked than that with amylobarbitone. It would seem therefore that tricyclic antidepressants are less likely than barbiturates, to bring about drug interactions by altering drug metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00562435
Permalink
