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  • 1
    Keywords: Medical microbiology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Biotechnology. ; Medical Microbiology. ; Biomedical Research. ; Pharmacology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: 1.Introduction to Drugs, Drug Targets and Drug Resistance -- 2.Drugs Resistance in Bacterial Diseases -- 3.Drugs Resistance Against Viral Diseases -- 4.Drug Resistance in Protozoal Infections -- 5.Antifungal Drugs: Mechanism of Action and Resistance -- 6.Drug Resistance in Ear, Nose, and Throat Infections -- 7.Drug Resistance in Skin Diseases -- 8.Drugs Resistance in Lungs Diseases -- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges -- 10.Drug Resistance in Kidney Diseases -- 11.Drugs resistance in Heart Diseases -- 12.Drugs Resistance in Liver Disease -- 13.Drug Resistance in Cancer -- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS -- 15.Drug Resistance in Reproductive Diseases -- 16.Drug Resistance in Diabetes -- 17.Drug Resistance in Rheumatological Diseases -- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response -- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization -- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat -- 21.Drugs Resistance Management.
    Abstract: This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included. .
    Type of Medium: Online Resource
    Pages: XI, 558 p. 97 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030763206
    DDC: 616.9041
    Language: English
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  • 2
    Keywords: Environmental chemistry. ; Diseases. ; Pharmacology. ; Environmental Chemistry. ; Diseases. ; Pharmacology.
    Description / Table of Contents: Part I: Introduction to endocrine system and metabolic disorders. - Chapter 1: Physiology of endocrine system and related metabolic disorders -- Chapter 2: Impaired carbohydrate metabolism in metabolic disorders -- Chapter 3: Mitochondrial dysfunction in metabolic disorders -- Chapter 4: Inherited metabolic disorders-a current status -- Chapter 5: Impaired lipid metabolism in metabolic disorders -- Chapter 6: Impaired thyroid function in metabolic disorders. - Part II: Role of endocrine disrupting chemicals in metabolic disorders -- Chapter 7: Endocrine-disrupting chemicals: Occurrence and exposure to the human being -- Chapter 8: Antibiotic resistance in EDCs-induced metabolic disorders -- Chapter 9: Alteration of gut microbiota in EDCs-induced metabolic disorders -- Chapter 10: Endocrine disrupting chemicals induced childhood obesity -- Chapter 11: Role of polychlorinated biphenyls as EDCs in metabolic disorders -- Chapter 12: Role of furans as EDCs in metabolic disorders -- Chapter 13: Role of heavy metals in metabolic disorders -- Chapter 14: Role of flame-retardants as EDCs in metabolic disorders -- Chapter 15: Role of phthalates as EDCs in metabolic disorders. - Chapter 16: Bisphenol A as an EDC in metabolic disorders -- Chapter 17: Role of pesticides as EDCs in metabolic disorders -- Chapter 18: Role of perfluoroalkyl substances as EDCs in metabolic disorders -- Chapter 19: Role of polycyclic aromatic hydrocarbons as EDCs in metabolic disorders -- Chapter 20: Tobacco smoking as an EDC in metabolic disorders -- Chapter 21: Role of pharmaceuticals as EDCs in metabolic disorders -- Chapter 22: Parabens as endocrine disrupting chemicals and their association with metabolic disorders -- Chapter 23: Role of aflatoxins as EDCs in metabolic disorders -- Part III: Treatment strategies of EDCs-induced metabolic disorders: From prevention to intervention -- Chapter 24: Hormone harmony in metabolic disorders -- Chapter 25: Role of nanoparticles in the management of metabolic disorders -- Chapter 26: Intermittent fasting for treatment of metabolic disorders -- Chapter 27: rbs and spices as natural medicine for treatment of metabolic disorders -- Chapter 28: Bioactive compounds for the treatment of metabolic disorders.
    Abstract: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
    Type of Medium: Online Resource
    Pages: XXV, 520 p. 176 illus., 98 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030459239
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    DDC: 577.14
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.
    Abstract: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
    Type of Medium: Online Resource
    Pages: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564260
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Plant physiology. ; Pharmacology. ; Plant biotechnology. ; Molecular biology. ; Ecology . ; Plant Physiology. ; Pharmacology. ; Plant Biotechnology. ; Molecular Biology. ; Ecology.
    Description / Table of Contents: Chapter 1. Medicinal plants and abiotic stress: An overview -- Chapter 2. Medicinal plants proteomics in response to abiotic stresses -- Chapter 3. Medicinal plants metabolomics in response to abiotic stresses -- Chapter 4. Secondary metabolite production in medicinal plants under abiotic stress -- Chapter 5. Effect of temperature (cold and hot) stress on medicinal plants -- Chapter 6. Effect of water stress (drought and waterlogging) on medicinal plants -- Chapter 7. Effects of gaseous pollutants on medicinal plants -- Chapter 8. Impact of salinity stress on medicinal plants -- Chapter 9. Impact of aridity on specialized metabolism: Concentration of natural products in plants -- Chapter 10.The role of PGPRs in medicinal plants under abiotic stress -- Chapter 11. Effect of mineral nutrition and PGRs on biosynthesis and distribution of secondary plant metabolites under abiotic stress -- Chapter 12. Impact of phytoprotectants on growth and yield of medicinal plants under abiotic stress -- Chapter 13. Biostimulants and phytohormones improve productivity and quality of medicinal plants under abiotic stress -- Chapter 14. Light (high light/UV radiation) modulates adaptation mechanisms and secondary metabolite production in medicinal plants -- Chapter 15. Recent Strategies to engineer alkaloid biosynthesis in medicinal plants -- Chapter 16. Genome-editing strategies for enhanced stress tolerance in medicinal plants -- Chapter 16. Phytoremediation potential of medicinal plants -- Chapter 17. Phytoremediation potential of medicinal plants.
    Abstract: This book provides a comprehensive overview of medicinal plants and their interaction with abiotic stress in terms of morphological, physiological, biochemical, and molecular variations, and explains the adaptation and tolerance mechanisms involved. It presents various mechanisms that become operative in medicinal plants to combat stressful situations. The book discusses the secondary metabolites and/or bioactive compounds produced in medicinal plants under abiotic stress conditions, and the use of biostimulants and/or phytoprotectants to alleviate the adverse effects of abiotic stresses on medicinal plants. Additionally, it is likely to address opportunities and challenges in molecular and omics studies of medicinal plants under abiotic stress conditions. Overall, the chapters are developed by eminent subject experts with due care and clarity and cover an up-to-date literature review with relevant illustrations. The book would cater to the need of graduate and post-graduate students, researchers as well as scientists, and may attract the attention of pharmaceutical companies/industrialists and health policymakers.
    Type of Medium: Online Resource
    Pages: XI, 469 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811956119
    DDC: 571.2
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environment. ; Neuropharmacology. ; Environmental chemistry. ; Pharmacology. ; Pollution. ; Neurosciences. ; Environmental Sciences. ; Neuropharmacology. ; Environmental Chemistry. ; Pharmacology. ; Pollution. ; Neuroscience.
    Description / Table of Contents: 1-Pathogenesis of neurodegeneration and associated neurological disorders -- 2-Air pollutants and neurological disorders: From exposure to preventive interventions -- 3-Bacterial endotoxins and neurological disorders: From exposure to preventive interventions -- 4-Heavy metals and neurological disorders: From exposure to preventive interventions -- 5-Pesticides and neurological disorders: From exposure to preventive interventions -- 6-Cigarette smoking and neurological disorders: From exposure to preventive interventions -- 7-Mycotoxins and neurological disorders: From exposure to preventive interventions -- 8-Polycarbonate plastics and neurological disorders: From exposure to preventive interventions -- 9-Bisphenol A and neurological disorders: From exposure to preventive interventions -- 10-Volatile organic compounds and neurological disorders: From exposure to preventive interventions -- 11-Persistent organic pollutants and neurological disorders: From exposure to preventive interventions -- 12-Polychlorinated biphenyls and neurological disorders: From pathogenesis and preventive interventions -- 13-Phthalates and neurological disorders: From exposure to preventive interventions -- 14-Perfluoroalkyl chemicals and neurological disorders: From exposure to preventive interventions -- 15-Polycyclic aromatic hydrocarbons and neurological disorders: From exposure to preventive interventions -- 16-Nanomaterials as source of environmental contaminants: from exposure to preventive interventions.
    Abstract: This volume discusses how environmental pollutants are involved in the pathogenesis of neurological disorders, and covers specific mechanisms and risk factors, as well as the necessary strategies to reduce the adverse impacts of environmental pollutants on the human nervous system. With a collection of contributions from experts in environmental pollution, neurology and pharmaceutical chemistry, the book provides both an introduction to the pathogenesis of neurodegeneration, including the types and different classes of neurological disorders, and studies demonstrating the clear link between environmental contaminants (e.g. pesticides, smoking, mycotoxins, persistent organic pollutants (POP's), polychlorinated biphenyls, phthalates, nanomaterials) and the development of neurological disorders in vulnerable populations. The book fills in a gap in research on the topic by also covering state-of-the-art treatment strategies and mitigation measures for each type of pollutant. The book will be of interest to environmental scientists, pharmacologists, toxicologists, biochemists, biotechnologists, and food and drug regulatory organizations.
    Type of Medium: Online Resource
    Pages: XII, 410 p. 81 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663766
    Series Statement: Emerging Contaminants and Associated Treatment Technologies,
    DDC: 333.7
    Language: English
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  • 6
    ISSN: 1042-7163
    Keywords: Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Organotin compounds with the general formula R2(X)SnL (where R=Me, Et, n-Bu, Ph; L=the trans-3-(2-furanyl)-2-propenoate anion or the trans-3-(3-methylphenyl)-2-propenoate anion; and X=Cl) have been prepared by redistribution reactions between the R2SnL2 and R2SnX2 compounds. These compounds were characterized by elemental analyses and various spectroscopic techniques such as 1H, 13C, 119Sn NMR, Mass, Mössbauer, and IR spectroscopies. On the basis of these spectroscopic data, it is suggested that these compounds adopt the cis-R2(X)SnO2 geometry. © 1997 John Wiley & Sons, Inc. Heteroatom Chem 8: 273-278, 1997.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Heteroatom Chemistry 7 (1996), S. 233-237 
    ISSN: 1042-7163
    Keywords: Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mechanism of the fluxional process occurring in dimeric tetraorganodicarboxylato stannoxanes is presented on the basis of multinuclear NMR studies carried out in noncoordinating solvents. This fluxional process is a consequence of rapid migration of carboxylate groups from one tin atom to the other. It has been proposed that larger carboxylates will also execute this behavior. The effect of cis and trans positions on the fluxional process is discussed. The fluxional process is very fast and could not be stopped even at low temperatures, as measured on the NMR time scale. © 1996 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 96 (1963), S. 1610-1617 
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ausgehend von 9-Formyl-fluoren, wurde ein spirocyclisches Cyclohexadienon-Derivat XI synthetisiert. Die Behandlung dieses Ketons mit Acetanhydird und Schwefelsäure führte unter Umlagerung zu Acetoxy-triphenylen. Nach Reduktion der Carbonylgruppe ergab die Umlagerung Triphenylen. Auf ähnliche Weise wurden auch Triphenylencarbonsäure und 2-Phenyl-triphenylen hergestellt.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 126 (1993), S. 2353-2355 
    ISSN: 0009-2940
    Keywords: Ylides ; Distonic ions ; Neutralization-reionization mass spectrometry ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The recently described (Maier et al.[2]) title compound is not only viable in an argon matrix (10 K) but is also accessible in the gas phase. Electron impact ionization of (CH3)3CCX2NC (X = H, D) gives rise to HCNCX2+, which can be successfully neutralized in a beam experiment.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 1171-1173 
    ISSN: 0009-2940
    Keywords: Tandem mass spectrometry ; Collision experiments ; Sulfur-nitrogen clusters ; Electron transfer ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Collision experiments on NS-x (x = 2, 3) clusters are reported. Evidence is presented for the gas-phase existence of the corresponding NS.x and NS+x species. For x = 3, the mass spectra are very much in keeping with a connectivity SS-NS (5) for all three charge states. For x = 2, the experimental data favor the presence of NSS (2); however, the cyclic C2v-symmetric form 3 cannot be ruled out.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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