ISSN:
1573-9171
Keywords:
4-amino-5-acetylpyrimidines
;
4-benzoylamino-5-acetylpyrimidines
;
dimethylformamide dimethylacetal
;
dimethylacetamide dimethylacetal
;
pyrido-[2,3-d]pyrimidin-5-ones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract New methods for annelation of a pyridine ring to a pyrimidine ring were suggested. Substituted 8H-pyrido[2,3-d]pyrimidin-5-ones (8a-f) were synthesized by the interaction of 2,6-disubstituted 4-amino-5-acetylpyrimidines (1–4) with formamide or acetamide acetals followed by cyclization under the action of sodium methoxide in methanol. 2,4-Disubstituted 7-phenyl-8H-pyrido[2,3-d]pyrimidin-5-ones (11a-c) were prepared by the reaction of 2,6-disubstituted 5-acetyl-4-benzoylaminopyrimidines (10a-c) with MeONa in boiling BuOH.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00703702
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