Publication Date:
1992-07-31
Description:
A chloride (Cl-)-dependent, nonselective cation conductance was activated during cellular shrinkage and inhibited during cellular swelling or by extracellular gadolinium. The shrinking-induced, nonselective cation conductance and the swelling-induced anion conductance appear to function in the regulation of cell volume in airway epithelia. The shrinking-induced cation conductance had an unusual dependence on Cl-: partial replacement of extracellular Cl- with aspartate reduced the magnitude of the shrinking-enhanced current without accompanying changes in the reversal potential. The Cl- dependence of the nonselective cation conductance could provide a mechanism that tightly regulates Cl- secretion and sodium reabsorption in cells under osmotic stress.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, H C -- Nelson, D J -- New York, N.Y. -- Science. 1992 Jul 31;257(5070):669-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Chicago, IL 60637.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1379742" target="_blank"〉PubMed〈/a〉
Keywords:
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
;
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid/analogs &
;
derivatives/pharmacology
;
Amiloride/pharmacology
;
Calcium/pharmacology
;
*Cations
;
Cell Membrane/*physiology
;
Cell Membrane Permeability
;
Cesium/metabolism
;
Chlorides/*pharmacology
;
Electric Conductivity
;
Epithelium/physiology/ultrastructure
;
Humans
;
Ion Channels/*physiology
;
Lithium/metabolism
;
Lung/physiology/ultrastructure
;
Membrane Potentials
;
Osmolar Concentration
;
Potassium/metabolism
;
Sodium/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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