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  • 1
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    HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-10
    Description: A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated "fusin," is a putative G protein-coupled receptor with seven transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD4-positive human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophagetropic HIV-1 isolates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feng, Y -- Broder, C C -- Kennedy, P E -- Berger, E A -- New York, N.Y. -- Science. 1996 May 10;272(5263):872-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8629022" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Amino Acid Sequence ; Animals ; Antigens, CD4/*physiology ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Cell Membrane/virology ; Chemokines/physiology ; *Cloning, Molecular ; DNA, Complementary/genetics ; Disease Models, Animal ; GTP-Binding Proteins/metabolism ; Giant Cells ; HIV Envelope Protein gp120/physiology ; HIV-1/*pathogenicity/physiology ; HeLa Cells ; Humans ; Leukocytes, Mononuclear/virology ; Macrophages/virology ; *Membrane Fusion ; Membrane Proteins/genetics/*physiology ; Mice ; Molecular Sequence Data ; RNA, Messenger/metabolism ; Receptors, CXCR4 ; Recombinant Proteins ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-06-28
    Description: Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1alpha, and MIP-1beta, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alkhatib, G -- Combadiere, C -- Broder, C C -- Feng, Y -- Kennedy, P E -- Murphy, P M -- Berger, E A -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1955-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658171" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Animals ; Antigens, CD4/physiology ; Cell Fusion ; Chemokine CCL3 ; Chemokine CCL4 ; Chemokine CCL5/metabolism/pharmacology ; Chemokines/*metabolism/pharmacology ; Gene Products, env/physiology ; Giant Cells/metabolism ; HIV-1/pathogenicity/*physiology ; HeLa Cells ; Humans ; Macrophage Inflammatory Proteins ; Macrophages/*virology ; Membrane Fusion ; Mice ; Monokines/metabolism/pharmacology ; Receptors, CCR5 ; Receptors, Cytokine/*physiology ; Receptors, HIV/*physiology ; Recombinant Proteins/pharmacology ; T-Lymphocytes/virology ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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