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  • 1
    Electronic Resource
    Electronic Resource
    Drug monitoring of quinine by HPLC in cerebral malaria with acute renal failure treated by haemofiltration (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 293-296 
    Details
    ISSN: 1432-1041
    Keywords: falciparum malaria ; quinine ; acute renal failure ; HPLC ; haemofiltration ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The monitoring of quinine by HPLC in 3 patients suffering from cerebral malaria with acute renal failure and treated by haemofiltration is reported. The recommended dose of quinine in this situation is reduced to 10 to 15 mg·kg−1·day−1. However, in the first patient, when given quinine 10 mg kg−1·day−1 the plasma concentration was mainly below the recommended therapeutic range of 5 to 15 mg/l. In consequence, the dose of quinine in the second patient was elevated to quinine dihydrochloride 15.1 mg·kg−1·day−1 which produced plasma concentrations in the low therapeutic range. In the third patient, an unreduced dose of quinine dihydrochloride 25.7 mg·kg−1·day−1 was employed, resulting in plasma concentrations above 15 mg/l, which is generally assumed to be toxic, although, no sign of acute quinine toxicity was seen. The antimalarial effect in all three patients was satisfactory. Quinine was estimated in the haemofiltrate in two patients and was found to be below the limit of sensitivity (0.25 mg/l). Plasma quinine did not change during or shortly after haemofiltration. It is concluded that in case of acute renal failure in cerebral malaria the dose of quinine should be reduced, but that the common recommendation of 10 to 15 mg·kg−1·day−1 may be too low, and that haemofiltration has no marked influence on the total body clearance of quinine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637565
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  • 2
    Electronic Resource
    Electronic Resource
    ConA induced changes in energy metabolism of rat thymocytes (1992)
    Springer
    Bioscience reports 12 (1992), S. 109-114 
    Details
    ISSN: 1573-4935
    Keywords: energy metabolism ; oxygen consumption ; thymocytes ; ConA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The influence of ConA on the energy metabolism of quiescent rat thymocytes was investigated by measuring the effects of inhibitors of protein synthesis, proteolysis, RNA/DNA synthesis, Na+K+-ATPase, Ca2+-ATPase and mitochondrial ATP synthesis on respiration. Only about 50% of the coupled oxygen consumption of quiescent thymocytes could be assigned to specific processes using two different media. Under these conditions the oxygen is mainly used to drive mitochondrial proton leak and to provide ATP for protein synthesis and cation transport, whereas oxygen consumption to provide ATP for RNA/DNA synthesis and ATP-dependent proteolysis was not measurable. The mitogen ConA produced a persistent increase in oxygen consumption by about 30% within seconds. After stimulation more than 80% of respiration could be assigned to specific processes. The major oxygen consuming processes of ConA-stimulated thymocytes are mitochondrial proton leak, protein synthesis and Na+K+-ATPase with about 20% each of total oxygen consumption, while Ca2+-ATPase and RNA/DNA synthesis contribute about 10% each. Quiescent thymocytes resemble resting hepatocytes in that most of the oxygen consumption remains unexplained. In contrast, the pattern of energy metabolism in stimulated thymocytes is similar to that described for Ehrlich Ascites tumour cells and splenocytes, which may also be in an activated state. Most of the oxygen consumption is accounted for, so the unexplained process(es) in unstimulated cells shut(s) off on stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02351215
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  • 3
    Electronic Resource
    Electronic Resource
    Cytophysiology of neurosecretory axon terminals in the brain of an annelid (Ophryotrocha puerilis, Polychaeta) (1991)
    Springer
    Cell & tissue research 264 (1991), S. 339-345 
    Details
    ISSN: 1432-0878
    Keywords: Neurosecretion ; Catecholamines ; HPLC ; Immunohistochemistry ; Glyoxylic acid fluorescence ; Ophryotrocha puerilis (Annelida)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the posterior part of the brain of the protandric polychaete Ophryotrocha puerilis neurosecretory cells form prominent axon terminals. The terminals are arranged in two complexes. The perikarya of these presumably monopolar neurons are scattered in the anterior part of the cerebral perikaryal layer. In females the terminals store large amounts of neurosecretory material. It has been suggested earlier that neurosecretions of the terminals may play a role during sex reversal from females to males. Application of histamine caused the release of neurosecretory material from the respective terminals in females. However, this discharge was not followed by sex reversal. Application of reserpine had no influence on the terminals. Neither by in vivo observation nor by ultrastructural analysis any effect of reserpine on the terminal complexes could be observed. In isolated terminals filled with neurosecretory material from females, catecholamines could not be detected by HPLC. Also, polyclonal antibodies against dopamine did not stain the terminal complexes. Furthermore, the complexes did not develop any fluorescence after glyoxylic acid treatment. Therefore, the present results contradict the hypothesis that the neurosecretory material of the respective axon terminals is catecholaminergic and that it is involved in sex differentiation. The function of the secretory neurons studied here remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313972
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  • 4
    Electronic Resource
    Electronic Resource
    ConA induced changes in energy metabolism of rat thymocytes (1992)
    Springer
    Bioscience reports 12 (1992), S. 381-386 
    Details
    ISSN: 1573-4935
    Keywords: energy metabolism ; oxygen consumption ; thymocytes ; ConA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The influence of ConA on the energy metabolism of quiescent rat thymocytes was investigated by measuring the effects of inhibitors of protein synthesis, proteolysis, RNA/DNA synthesis, Na+K+-ATPase, Ca2+-ATPase and mitochondrial ATP synthesis on respiration. Only about 50% of the coupled oxygen consumption of quiescent thymocytes could be assigned to specific processes using two different media. Under these conditions the oxygen is mainly used to drive mitochondrial proton leak and to provide ATP for protein synthesis and cation transport, whereas oxygen consumption to provide ATP for RNA/DNA synthesis and ATP-dependent proteolysis was not measurable. The mitogen ConA produced a persistent increase in oxygen consumption by about 30% within seconds. After stimulation more than 80% of respiration could be assigned to specific processes. The major oxygen consuming processes of ConA-stimulated thymocytes are mitochondrial proton leak, protein synthesis and Na+K+-ATPase with about 20% each of total oxygen consumption, while Ca2+-ATPase and RNA/DNA synthesis contribute about 10% each. Quiescent thymocytes resemble resting hepatocytes in that most of the oxygen consumption remains unexplained. In constrast, the pattern of energy metabolism in stimulated thymocytes is similar to that described for Ehrlich Ascites tumour cells and splenocytes, which may also be in an activated state. Most of the oxygen consumption is accounted for, so the unexplained process(es) in unstimulated cells shut(s) off on stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01121501
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  • 5
    Electronic Resource
    Electronic Resource
    The state dependence of the interaction of metastable rare gas atoms Rg*(ms3 P 2,3 P 0) (Rg=Ne, Ar, Kr, Xe) with ground state sodium atoms (1990)
    Springer
    The European physical journal 16 (1990), S. 237-249 
    Details
    ISSN: 1434-6079
    Keywords: 31.20Pv ; 31.50.+w ; 31.70.−f ; 34.20.−b ; 34.50.Gb ; 35.20.Gs ; 82.40.Dm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using crossed beams of metastable rare gas atoms Rg*(ms3 P 2,3 P 0) (Rg=Ne, Ar, Kr, Xe) and ground state sodium atoms Na(3s 2 S 1/2), we have measured the energy spectra of electrons released in the respective Penning ionization processes at thermal collision energies. For Rg*(3 P 2)+Na(3s), the spectra are quite similar for the different rare gases, both in width and shape; they reflect attractive interactions in the entrance channel with well depthsD* e [meV] decreasing slowly from Rg=Ne to Xe as follows: 676(18); 602(23); 565(26); 555(30). For Rg*(3 P 0)+Na(3s), the spectra vary strongly with the rare gas, indicating a change in the character of the interaction from van der Waals type attraction (Ne) to chemical binding for Kr and Xe with well depthsD* e [meV] of: 51(19); 107(25); 432(30); 530(50). These findings are explained through model calculations of the respective potential curves, in which the exchange and the spin orbit interaction in the excited rare gas and the molecular interaction between the two valences-electrons in terms of suitably chosen singlet and triplet potentials are taken into account. These calculations also explain qualitatively the experimental finding that the ratiosq 2/q 0 of the ionization cross sections for Rg*(3 P 2)+Na and Rg*(3 P 0)+Na vary strongly with the rare gas from Ne to Xe as follows: 15.8(3.2); 2.6(4); 1.4(2); 1.6(4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437526
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental and theoretical studies of the Bi-excited collision systems He*(23 S) + He*(23 S, 21 S) at thermal and subthermal kinetic energies (1991)
    Springer
    The European physical journal 21 (1991), S. 89-112 
    Details
    ISSN: 1434-6079
    Keywords: 31.20.Di ; 34.50.Gb ; 52.20.Hv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have carried out a comprehensive experimental and theoretical investigation of the autoionizing collision systems He*(23 S, 21 S) + He*(23 S). We present high resolution electron energy spectra, obtained with a single He* beam (average relative collision energy 〈E rel〉=1.6 meV) and with crossed He* beams (〈E rel〉〉 =61 meV). The spectra show substantial structure, and under single beam conditions fast oscillations due to the interference of incoming and outgoing heavy particle waves in the entrance channels are observed. Accurate ab initio potential curves for the seven lowest He*—He*(Σ) molecular states have been obtained from a Feshbach projection scheme, and width functions for He*(23 S) + He*(23 S) have been derived by Stieltjes imaging. Based on these ab initio data, detailed quantum mechanical calculations of the electron spectra have been carried out and provide a thorough understanding of the experimentally observed spectral features. Good overall agreement of the calculated spectra with the experimental data is observed. The close coincidence in the positions of the experimental and theoretical peaks, especially for He*(23 S) + He*(23 S), underlines the reliability of the ab initio potentials. In the He*(21 S) + He*(23 S) electron spectrum, the dominant peak is traced to be due to autoionization from the 23Σ+ g molecular state accessed via an avoided crossing. We also present a detailed discussion of the total ionization cross sections σtot and of the fraction σAI/σtot for associative ionization together with a critical comparison with previous work. The ionization probabilities for close collisions in entrance channels, from which autoionization is spin-allowed, are near unity, and therefore the absolute values and the collision energy dependence of the total cross sections simply reflect the long-range behaviour of the excited state potentials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01425589
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  • 7
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    Prompt neutron polarization asymmetries in photofission of Th232, U233,235,238, Np237, and Pu239,240 (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-03-20
    Description: Author(s): J. M. Mueller, M. W. Ahmed, R. H. France, III, M. S. Johnson, H. J. Karwowski, L. S. Myers, J. Randrup, M. H. Sikora, M. C. Spraker, S. Stave, J. R. Tompkins, R. Vogt, H. R. Weller, C. S. Whisnant, and W. R. Zimmerman Photofission experiments were performed on targets of Th232, U233,235,238, Np237, and Pu239,240 using nearly 100% linearly polarized, high intensity (∼5×106γ/s), and nearly-monoenergetic γ-ray beams having energies between 5.3 and 7.6 MeV at the High Intensity γ-ray Source (HIγS) located at Duke Uni... [Phys. Rev. C 89, 034615] Published Wed Mar 19, 2014
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Measurement of prompt neutron polarization asymmetries in photofission of ^{235,238}U, ^{239}Pu, and ^{232}Th (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-01-12
    Description: Author(s): J. M. Mueller, M. W. Ahmed, B. Davis, J. M. Hall, S. S. Henshaw, M. S. Johnson, H. J. Karwowski, D. Markoff, L. S. Myers, B. A. Perdue, S. Stave, J. R. Tompkins, M. J. Tuffley, and H. R. Weller [Phys. Rev. C 85, 014605] Published Wed Jan 11, 2012
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
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    Compton scattering from Li6 at 86 MeV (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-08-27
    Description: Author(s): L. S. Myers, M. W. Ahmed, G. Feldman, A. Kafkarkou, D. P. Kendellen, I. Mazumdar, J. M. Mueller, M. H. Sikora, H. R. Weller, and W. R. Zimmerman Cross sections for Li6(γ,γ)Li6 have been measured at the High Intensity Gamma-Ray Source (HIγ⃗S) and the sensitivity of these cross sections to the nucleon isoscalar polarizabilities was studied. Data were collected using a quasimonoenergetic 86-MeV photon beam at photon scattering angles of 40∘–160... [Phys. Rev. C 90, 027603] Published Tue Aug 26, 2014
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    Polarization asymmetries in the ^{9} Be(γ,n_{0} ) reaction (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-09-11
    Description: Author(s): J. M. Mueller, M. W. Ahmed, B. J. Davis, H. J. Karwowski, D. M. Markoff, L. S. Myers, M. C. Spraker, S. Stave, J. R. Tompkins, H. R. Weller, and W. R. Zimmerman Measurements of the Be 9 ( γ , n 0 ) reaction were performed using nearly 100% linearly polarized, high-intensity, and nearly monoenergetic γ -ray beams having energies between 5.5 and 15.5 MeV at the High Intensity γ -ray Source located at Duke University and Triangle Universities Nuclear Laboratory. Eighte… [Phys. Rev. C 92, 034604] Published Thu Sep 10, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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