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  • General Chemistry  (3)
  • 2D NMR  (2)
  • Arborescidine  (1)
  • Farming trials  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Crystal structure and absolute configuration of the indole alkaloid arborescidine C (1998)
    Springer
    Journal of chemical crystallography 28 (1998), S. 23-26 
    Details
    ISSN: 1572-8854
    Keywords: Arborescidine ; indole alkaloid ; marine compound ; absolute configuration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The structure and absolute configuration (3R, 17R) of the indole alkaloid arborescidine C were determined by x-ray diffraction. The six-membered ring assumes a half-chair conformation and the seven-membered ring has a twist-like conformation. The crystal packing is characterized by intermolecular hydrogen-bonding between the hydroxyl group and nitrogen atom N4 which leads to the formation of infinite chains of molecules along the a-axis of the crystal. The absolute configurations of two related indole alkaloids, arborescidine B and arborescidine D are inferred from the experimentally determined configuration of arborescidin C molecule. A comparison of the present structure with that of a related indole alkaloid akagerine showed significant conformational and configurational differences. Crystal data: C16H19N2OBr, orthorhombic, P21212, a = 10.3376(8), b = 15.461(4), c = 9.2094(9)Å, V = 1471.9(6)Å3, Z = 4, D calc = 1.510 g cm−3, λ = 1.54178Å.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021770401042
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Isolation and Structural Elucidation of Crellastatins B-H: Cytotoxic Bis(steroid) Derivatives from the Vanuatu Marine Sponge Crella sp. (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 949-953 
    Details
    ISSN: 1434-193X
    Keywords: Natural products ; Dimeric steroids ; Crellastatins ; Sponge ; Crella sp. ; 2D NMR ; Antitumor agents ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -Seven new cytotoxic dimeric steroids, namely crellastatins B-H (2-8), have been isolated from the Vanuatu sponge Crella sp. They have been structurally characterized on the basis of 2D-NMR (500 MHz) and FAB-MS data. All the new compounds show the same unprecedented junction between the monomeric units, formed via their side-chains, whereas they differ from A (1) in the hydroxylation pattern of the two tetracyclic cores. Like crellastatin A (1), crellastatins B-H (2-8) exhibit in vitro antitumor activity against human bronchopulmonary non-small-cell lung carcinoma cell lines (NSCLC) with IC50 values in the range of 2-10 μg/mL.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    Axinellins A and B: New Proline-Containing Antiproliferative Cyclopeptides from the Vanuatu Sponge Axinella carteri (1998)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1998 (1998), S. 2659-2665 
    Details
    ISSN: 1434-193X
    Keywords: Natural products ; Amino acids ; Peptides ; Macrocycles ; Axinella carteri ; Sponge ; Cyclopeptides ; 2D NMR ; ESMS ; MS ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two new bioactive cyclopeptides, named axinellins A (1) and B (2) have been isolated from the marine sponge Axinella carteri. Their structure elucidation was based on two-dimensional (2D) NMR (500 MHz) as well as HRFABMS and ESMS/MS data. All amino acid residues derived from axinellins A and B were found to possess L configuration at Cα by HPLC analysis of their FDAA derivatives (Marfey's method). The amino acid sequence of 1 and 2 was established on the basis of tandem mass spectrometry data (ESMS/MS) and on 1H-1H through-space connectivities observed in NOESY and ROESY spectra. Axinellins A (1) and B (2) exhibited moderate in vitro antitumor activity against human broncopulmonary non-small-cell-lung-carcinoma lines (NSCLC-N6) with IC50 values of 3.0 and 7.3 μg/ml, respectively.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 4
    Electronic Resource
    Electronic Resource
    Plakinamines C and D and Three Other New Steroidal Alkaloids from the Sponge Corticium sp. (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 697-701 
    Details
    ISSN: 1434-193X
    Keywords: Corticium sp. ; Steroids ; Alkaloids ; Secondary metabolites ; Cytotoxic activity ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis, including 2D-HMBC and ROESY correlation experiments. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-N6) with IC50 values of 〈 3.3-5.7 μg/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 5
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    Prokaryotic communities of the French Polynesian sponge Dactylospongia metachromia display a site-specific and stable diversity during an aquaculture trial (2024)
    In:  Antonie van Leeuwenhoek vol. 117 no. 1
    Details
    Publication Date: 2024-04-26
    Description: Dynamics of microbiomes through time are fundamental regarding survival and resilience of their hosts when facing environmental alterations. As for marine species with commercial applications, such as marine sponges, assessing the temporal change of prokaryotic communities allows us to better consider the adaptation of sponges to aquaculture designs. The present study aims to investigate the factors shaping the microbiome of the sponge Dactylospongia metachromia, in a context of aquaculture development in French Polynesia, Rangiroa, Tuamotu archipelago. A temporal approach targeting explants collected during farming trials revealed a relative high stability of the prokaryotic diversity, meanwhile a complementary biogeographical study confrmed a spatial specifcity amongst samples at diferent longitudinal scales. Results from this additional spatial analysis confrmed that diferences in prokaryotic communities might frst be explained by environmental changes (mainly temperature and salinity), while no signifcant efect of the host phylogeny was observed. The core community of D. metachromia is thus characterized by a high spatiotemporal constancy, which is a good prospect for the sustainable exploitation of this species towards drug development. Indeed, a microbiome stability across locations and throughout the farming process, as evidenced by our results, should go against a negative infuence of sponge translocation during in situ aquaculture.
    Keywords: Holobiont ; Marine sponges ; Microbiome ; Farming trials ; Biogeography ; French Polynesia
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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