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  • 25.40.Sc  (1)
  • Chloroquine  (1)
  • Drug stability  (1)
  • 1
    ISSN: 1434-601X
    Keywords: 25.40.Sc ; 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have studied the fragmentation of Au projectiles interacting with targets of C, Al and Cu at an incident energy ofE/A=600 MeV. The employed inverse kinematics allowed a nearly complete detection of projectile fragments with chargeZ≧2. The recorded fragmentation events were sorted according to three observables, the multiplicityM lp of light charged particles, the largest atomic numberZ max within an event, and a new observable,Z bound, representing the sum of the atomic numbersZ of all fragments withZ≧2. Using these observables, the impact parameter dependence of the fragmentation process was investigated. For all three targets, a maximum mean multiplicity of 3 to 4 intermediate mass fragments (IMFs) is observed. The corresponding impact parameters range from central collisions for theC target to increasingly peripheral collisions for the heavier targets. It is found that the correlation between the IMF multiplicity andZ bound, extending from evaporation type processes (largeZ bound) to the total disassembly of the projectile (smallZ bound), is independent of the target nucleus. This universal behaviour may suggest an — at least partial — equilibration of the projectile fragment prior to its decay.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 10 (1988), S. 170-172 
    ISSN: 1573-739X
    Keywords: Chloroquine ; Citric acid ; Drug stability ; Parabens ; Preservatives, pharmaceutical ; Sorbic acid ; Syrup
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.
    Type of Medium: Electronic Resource
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