ISSN:
0739-4462
Keywords:
metoxadiazone [3-(2-methoxyphenyl)-5-methoxy-1, 3, 4-oxadiazol-2-one]
;
3-(2-methoxy-4-methylphenyl)-5-methoxy-1, 3, 4-oxadiazol-2-one
;
3-tolyl N-propylcarbamate
;
2-sec-butylphenyl N-methylcarbamate
;
3-tolyl N-methylcarbamate
;
2-isopropylpheynyl N-methylcarbamate
;
acetylcholinesterase
;
synergism
;
insecticide combination
;
Chemistry
;
Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
Notes:
The use of insecticide mixtures is generally considered to result in the simultaneous development of resistance to the components. However, experiences with leaf and planthoppers do not necessarily support this opinion and indicate that the N-methylcarbamate/N-propylcarbamate combination can overcome the resistance of the green rice leafhopper (GRLH) by synergism between the two components. It was found that the N-methylcarbamate/oxadiazolone combination gave a similar but more remarkable synergism than the former combination. The mechanism of synergism was studied by the analysis of acetylcholinesterase (AChE) inhibition using the log v-t plot. AChE from the resistant population is provided with two active sites, one being sensitive to N-methylcarbamate and oxadiazolone compounds and the other being insensitive to N-methylcarbamates but highly sensitive to oxadiazolones. The overall results indicate that the biochemical mechanism of action of the N-methylcarbamat/oxadiazolone combination is essentially the same as that of the N-methylcarbamate/N-propylcarbamate combination. Selection of susceptible GRLH by a N-methylcarbamate developed the cross-resistance to the whole N-methylcarbamate group; but the population became more susceptible to N-propylcarbamates. When further selected by the N-methylcarbamate/N-propylcarbamate combination, no further resistance developed to the combination or its components. Thus, certain combinations of insecticides may be useful in resistance management. © 1993 Wiley-Liss, Inc.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/arch.940220120
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