ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles  (4)
  • SO2  (2)
  • 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics  (1)
  • 3D model  (1)
  • 1
    ISSN: 1573-4951
    Keywords: Cytochromes P450 ; P450 2D6 ; P450 101 ; 3D model ; Active site residues ; Homology building
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A homology model building study of cytochrome P450 2D6 has been carried out based on the crystal structure of cytochrome P450 101. The primary sequences of P450 101 and P450 2D6 were aligned by making use of an automated alignment procedure. This alignment was adjusted manually by matching α-helices (C, D, G, I, J, K and L) and β-sheets (β3/β4) of P450 101 that are proposed to be conserved in membrane-bound P450s (Ouzounis and Melvin [Eur. J. Biochem., 198 (1991) 307]) to the corresponding regions in the primary amino acid sequence of P450 2D6. Furthermore, α-helices B, B′ and F were found to be conserved in P450 2D6. No significant homology between the remaining regions of P450 101 and P450 2D6 could be found and these regions were therefore deleted. A 3D model of P450 2D6 was constructed by copying the coordinates of the residues from the crystal structure of P450 101 to the corresponding residues in P450 2D6. The regions without a significant homology with P450 101 were not incorporated into the model. After energy-minimization of the resulting 3D model of P450 2D6, possible active site residues were identified by fitting the substrates debrisoquine and dextrometorphan into the proposed active site. Both substrates could be positioned into a planar pocket near the heme region formed by residues Val370, Pro371, Leu372, Trp316, and part of the oxygen binding site of P450 2D6. Furthermore, the carboxylate group of either Asp100 or Asp301 was identified as a possible candidate for the proposed interaction with basic nitrogen atom(s) of the substrates. These findings are in accordance with a recently published predictive model for substrates of P450 2D6 [Koymans et al., Chem. Res. Toxicol., 5 (1992) 211].
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2021-12-23
    Description: At open-vent basaltic volcanoes, resolving the activity escalation that heralds larger, potentially harmful eruptions is challenged by the persistent mild ordinary activity, which often masks the precursory unrest signals related to heightened magma transport from depth. Gas (SO2 and CO2) fluxes at surface are controlled by rate of magma transport and degassing within the magma plumbing system, and thus constitute key parameters to infer deep magma budget and dynamics. Here, we use several year-long (2014-present) gas observations at Etna and Stromboli volcanoes, in Sicily, to provide new evidence for the utility of long-term instrumental gas monitoring in real-time detecting the early phase of unrest prior eruption, and for characterizing syn-eruptive dynamics. To this aim, we use information from a gas monitoring network of permanent ultraviolet (UV) cameras and automatic Multi-Gas instruments that, combined with geophysical observations, allow characterizing changes in degassing and eruptive dynamics at high temporal/spatial resolution. Our results show that the paroxysmal (lava fountaining) explosions that periodically interrupted persistent open-vent activity on Etna (during 2014-2020) were accompanied by systematic, repetitive SO2 emission patterns prior, during, and after eruptions. These allow us identifying the characteristic pre- syn- and post- eruptive degassing regimes, and to establish thresholds in the SO2 flux record that mark phases of unrest. On Stromboli, the much improved temporal/spatial resolution of UV cameras allows resolving the escalation of regular strombolian activity, and its concentration toward its North-east crater, that heralds onset of effusive eruptions. During effusive eruption, although magma level drops in the conduit and explosive summit activity ceases, UV camera observations can still detect explosive gas bursts deep in the conduit while no infrasonic activity is detected. Combining the UV camera-derived SO2 fluxes with CO2/SO2 ratio records measured by the Multi-Gas, the CO2 flux can be inferred. We find that such CO2 flux time-series can allow tracking degassing of deeply stored mafic magma months before Stromboli"s eruptions. We finally show that remotely sensed gas emission and thermal activity can be combined together to characterize the dynamics of shallow magmatic system prior to and during unrest, ultimately helping to define timing of magma re-charging events driving the eruptions.
    Description: Published
    Description: Virtual
    Description: 4V. Processi pre-eruttivi
    Description: 5V. Processi eruttivi e post-eruttivi
    Keywords: Open vent volcanism ; SO2 ; UV cameras
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2022-08-25
    Description: We examine the tectonic evolution and structural characteristics of the Quaternary intermontane Mugello, Casentino, and Sansepolcro basins, in the Northern Apennines fold-andthrust belt. These basins have been classically interpreted to have developed under an extensional regime, and to mark the extension-compression transition. The results of our study have instead allowed framing the formation of these basins into a compressive setting tied to the activity of backthrust faults at their northeastern margin. Syndepositional activity of these structures is manifested by consistent architecture of sediments and outcrop-scale deformation. After this phase, the Mugello and Sansepolcro basins experienced a phase of normal faulting extending from the middle Pleistocene until Present. Basin evolution can be thus basically framed into a two-phase history, with extensional tectonics superposed onto compressional structures. Analysis of morphologic features has revealed the occurrence of fresh fault scarps and interaction of faulting with drainage systems, which have been interpreted as evidence for potential ongoing activity of normal faults. Extensional tectonics is also manifested by recent seismicity, and likely caused the strong historical earthquakes affecting the Mugello and Sansepolcro basins. Qualitative comparison of surface information with depth-converted seismic data suggests the basins to represent discrete subsiding areas within the seismic belt extending along the axial zone of the Apennines. The inferred chronology of deformation and the timing of activity of normal faults have an obvious impact on the elaboration of seismic hazard models.
    Description: Published
    Description: 336-356
    Description: 2T. Deformazione crostale attiva
    Description: JCR Journal
    Description: open
    Keywords: Northern Apennines ; Basin evolution ; structural analysis ; active tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2024-01-26
    Description: We used two and a half years long SO2 flux record, obtained using permanent ultraviolet cameras, to characterize changes in degassing dynamics at Mt. Etna volcano from summer 2014 to the end of 2016. Volcanic activity at Mt. Etna was characterized by persistent open-vent degassing periodically interrupted by intense paroxysmal lava fountaining events (in August 2014, December 2015, and May 2016). Results revealed systematic SO2 emission patterns prior, during, and after Etna’s paroxysmal phases, allowing us to identify thresholds between pre-syn-and post-eruptive degassing regimes. The SO2 flux typically peaked during a lava fountain: in the 18 May 2016 example, the averaged SO2 degassing rate was ~158 kg/s, the peak emission was ~260 kg/s, and the total released SO2 mass was ~1700 tons (in 3h). Paroxysmal explosive activity at NSE crater on 11-15 August 2014 was also associated with intense syneruptive SO2 degassing (at 30-40 kg/s levels on a daily average), and was preceded by onset in degassing activity at the same crater 4 days before. During paroxysmal activity on 3-5 December 2015, the SO2 fluxes peaked at 54-103 kg/s from VOR crater, and was preceded by a sizable increase from 10 kg/s (end of November) up to 45.5 kg/s, two days before. The May 16-25 2016 paroxysmal activity was characterized by intense degassing ~2 times higher than the 2016 average (~18 kg/s) and preceded by mild but detectable SO2 flux increases more than one month before its onset. Taken together, our observations, when combined with independent geophysical (thermal and seismic) evidence, allow us to fully characterize the Etna’s degassing dynamics and contribute to our understanding of its shallow plumbing system.
    Description: Published
    Description: Catania
    Description: OSV2: Complessità dei processi vulcanici: approcci multidisciplinari e multiparametrici
    Keywords: SO2 ; Mt. Etna volcano ; permanent ultraviolet cameras
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Abstract
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...