ISSN:
1573-3904
Keywords:
Aspartimide formation
;
β-Peptides
;
Cyclic peptides
;
Fluorenylmethyl protection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract α-Aspartyl-containing cyclic pentapeptides were synthesised in high yields using astrategy that maintained fluorenylmethyl protection on the aspartic acid side chain during chainassembly, resin cleavage and cyclisation of the linear precursors. Tetra-n-butylammoniumfluoride treatment of the fluorenylmethyl-protected cyclic peptides catalysed imide formation,whereas piperidine-induced deprotection resulted in good yields of the target cyclic peptides.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008878017315
Permalink