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  • 1
    Electronic Resource
    Electronic Resource
    Activation of microcarrier-attached lymphocytes in microgravity (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 40 (1992), S. 991-996 
    Details
    ISSN: 0006-3592
    Keywords: lymphocytes ; space biology ; bioprocessing in space ; interferon ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A technology has been developed to achieve optimal attachment of adhesion-independent lymphocytes to microcarrier beads. The activation of T-lymphocytes by concanavalin A was tested under microgravity conditions in an experiment carried out in space during the first Spacelab Life Science Mission. Activation, measured as the synthesis of deoxyribonucleic acid (DNA) and the production of interferon-gamma, more than doubled in attached lymphocytes in microgravity. The depression of the activation discovered in previous space experiments is due to an impairment not of the lymphocyte but of the macrophage function. The system described here may be useful for radiobiological investigations on the effect of high-energy particles and for testing the efficiency of the immune system in humans during the long-duration space flight planned in the future. The biotechnological significance of the increased lymphokine production in space remains to be assessed. © 1992 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260400815
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    Paper (German National Licenses)
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  • 2
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    Cell sensitivity to gravity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-13
    Description: Cultures of human lymphocytes exposed in microgravity to the mitogen concanavalin A showed less than 3 percent of the activation of ground controls. This result supports the hypothesis, based on simulations at low g and experiments at high g, that microgravity depresses whereas high gravity enhances cell proliferation rates. The effects of gravity are particularly strong in cells undergoing differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cogoli, A -- Tschopp, A -- Fuchs-Bislin, P -- New York, N.Y. -- Science. 1984 Jul 13;225(4658):228-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6729481" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; *Cell Physiological Phenomena ; Concanavalin A/pharmacology ; Humans ; Lymphocyte Activation/drug effects ; Lymphocytes/drug effects/physiology ; Space Flight ; *Weightlessness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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