Publication Date:
1992-06-12
Description:
Potent immunological adjuvants are urgently required to complement recombinant and synthetic vaccines. However, it has not been possible to derive new principles for the design of vaccine adjuvants from knowledge of the mechanism of immunogenicity. Carbonyl-amino condensations, which are essential to the inductive interaction between antigen-presenting cells and T helper cells, were tested as a target for the enhancement of immune responses. Enzymic oxidation of cell-surface galactose to increase aminereactive carbonyl groups on murine lymphocytes and antigen-presenting cells provided a potent, noninflammatory method of enhancing the immunogenicity of viral, bacterial, and protozoal subunit vaccines in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zheng, B -- Brett, S J -- Tite, J P -- Lifely, M R -- Brodie, T A -- Rhodes, J -- New York, N.Y. -- Science. 1992 Jun 12;256(5063):1560-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1598588" target="_blank"〉PubMed〈/a〉
Keywords:
*Adjuvants, Immunologic
;
Animals
;
Antibody Formation
;
Cytotoxicity, Immunologic
;
Galactose/*metabolism
;
Galactose Oxidase/*administration & dosage
;
HIV Envelope Protein gp120/immunology
;
Lymphocyte Activation
;
Mice
;
Neuraminidase/administration & dosage
;
Oxidation-Reduction
;
Peptides/immunology
;
T-Lymphocytes/*immunology
;
Vaccination/*methods
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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