Publication Date:
1999-12-03
Description:
Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein-2 (BMP-2) gene in bone cells. Lovastatin and simvastatin increased bone formation when injected subcutaneously over the calvaria of mice and increased cancellous bone volume when orally administered to rats. Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mundy, G -- Garrett, R -- Harris, S -- Chan, J -- Chen, D -- Rossini, G -- Boyce, B -- Zhao, M -- Gutierrez, G -- New York, N.Y. -- Science. 1999 Dec 3;286(5446):1946-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA. mundy@uthscsa.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10583956" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bone Density/*drug effects
;
Bone Morphogenetic Protein 2
;
Bone Morphogenetic Proteins/biosynthesis/genetics/pharmacology
;
Cell Line
;
Female
;
Fibroblast Growth Factor 1
;
Fibroblast Growth Factor 2/pharmacology
;
Humans
;
Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology
;
Lovastatin/*pharmacology
;
Male
;
Mice
;
Mice, Inbred ICR
;
Organ Culture Techniques
;
Osteoblasts/*drug effects/metabolism
;
Osteoclasts/drug effects
;
Osteogenesis/*drug effects
;
Osteoporosis/drug therapy
;
Ovariectomy
;
Promoter Regions, Genetic/drug effects
;
Rats
;
Recombinant Proteins/pharmacology
;
Simvastatin/*pharmacology
;
Skull
;
Transfection
;
*Transforming Growth Factor beta
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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