Publication Date:
2001-01-06
Description:
Directed cell migration is important for many aspects of normal animal development, but little is known about how cell migrations are guided or the mechanisms by which guidance cues are translated into directed cell movement. Here we present evidence that signaling mediated by the epidermal growth factor receptor (EGFR) guides dorsal migration of border cells during Drosophila oogenesis. The transforming growth factor-alpha (TGF-alpha)-like ligand Gurken appears to serve as the guidance cue. To mediate this guidance function, EGFR signals via a pathway that is independent of Raf-MAP kinase and receptor-specific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duchek, P -- Rorth, P -- New York, N.Y. -- Science. 2001 Jan 5;291(5501):131-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11141565" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Cell Movement
;
*Drosophila Proteins
;
Drosophila melanogaster/*cytology/genetics/*physiology
;
Female
;
Insect Proteins/genetics/physiology
;
Ligands
;
MAP Kinase Signaling System
;
Mitogen-Activated Protein Kinases/metabolism
;
Mutation
;
*Neuregulins
;
Oocytes/cytology/physiology
;
Oogenesis
;
Ovarian Follicle/cytology/physiology
;
Proto-Oncogene Proteins c-raf/metabolism
;
Receptor, Epidermal Growth Factor/genetics/*physiology
;
*Signal Transduction
;
*Transforming Growth Factor alpha
;
Transforming Growth Factors/genetics/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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