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  • Polymer and Materials Science  (6)
  • *Signal Transduction  (1)
  • Cell Membrane/metabolism  (1)
  • 1
    Publication Date: 1993-04-23
    Description: The CD45 protein is a transmembrane tyrosine phosphatase that is required for normal T cell receptor (TCR)-mediated signaling. A chimeric complementary DNA encoding the intracellular enzymatically active portion of murine CD45 preceded by a short amino-terminal sequence from p60c-src was transfected into CD45- T cells. Expression of this chimeric protein corrected most of the TCR signaling abnormalities observed in the absence of CD45, including TCR-mediated enhancement of tyrosine kinase activity and Ca2+ flux. Thus, the enzymatically active intracellular portion of CD45 is sufficient to allow TCR transmembrane signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Volarevic, S -- Niklinska, B B -- Burns, C M -- June, C H -- Weissman, A M -- Ashwell, J D -- New York, N.Y. -- Science. 1993 Apr 23;260(5107):541-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8475386" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD3/immunology ; Antigens, CD45/genetics/*metabolism ; Base Sequence ; Calcium/metabolism ; Cell Membrane/metabolism ; Membrane Proteins/metabolism ; Mice ; Molecular Sequence Data ; Phosphorylation ; Protein-Tyrosine Kinases/metabolism ; Receptors, Antigen, T-Cell/*metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Tumor Cells, Cultured ; Tyrosine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 16 (1972), S. 1309-1312 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 26 (1981), S. 1295-1300 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Shifts have been observed in the elution volumes of solutions of polystyrene, polybutadiene, and mixtures of the two in gel permeation chromatography using tetrahydrofuran as solvent. Such shifts are examined in terms of the effect on the hydrodynamic volumes of concentration, of molecular weight, and of the presence of an incompatible polymer. Suitable concentration ranges to minimize these shifts have been found.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 15 (1971), S. 1995-2006 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The incompatibility of polystyrene and poly(methyl methacrylate) in benzene was examined at 20.1°, 40.0°, and 60.2°C. The incipient cloud points of solutions of equal weights of the two polymers were determined by a novel photometric method. Polystyrene samples with weight-average molecular weights in the range of 3.27 × 105 to 6.43 × 104 and poly(methyl methacrylate) samples with weight-average molecular weights in the range of 8.97 × 105 to 8.76 × 104 were used. Models describing the dependence on molecular weight of the critical concentration of a ternary polymer-polymer-solvent system, presented by Fuchs and by Kuhn et al., were examined in light of the experimental data. A modified model is proposed which gives an improved correlation of these results.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 34 (1987), S. 1835-1859 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The transport of gaseous ethylene oxide (EtO) in several polymer films is studied using the carrier gas method of measurement. Permeability, solubility, and diffusion coefficients describing ethylene oxide (EtO) transport in polypropylene, polyvinylchloride, Teflon-FEP copolymer, and polyethylene films have been obtained over a 30 Celsius degree range at a low concentration of EtO using the carrier gas method of measurement. The results indicate that the diffusion of EtO in polyethylene is independent of penetrant concentration over the range of concentrations used. However, concentration-independent diffusion could not be verified directly for the other films studied. Two different techniques of determining diffusion coefficients were used, and within the precision of the data both yield the same result. An excess enthalpy of solution for the solubility of EtO in Teflon-FEP copolymer was calculated, an observation that suggests that dual-mode sorption may be taking place.
    Additional Material: 19 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 13 (1975), S. 2291-2304 
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics and molecular weight distributions (MWD) of the gamma-ray induced polymerization of styrene in methanol were studied at 35°C, at low conversions and over a dose rate range of 2.76 × 103 to 2.74 × 104 rad/hr. The data obtained at low initial methanol content agreed with previously obtained results and the MWD of the polystyrene formed yielded a single unimodal peak with M̄n in the range of 35,000-480,000. However, at high initial methanol content and low dose rates, at least three peaks were clearly discernible over wide molecular weight distributions. The existence of these peaks is related to the kinetic data and the formation of three distinguishable regions in the polymerization system.
    Additional Material: 15 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 7 (1969), S. 333-349 
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Poly-2,6-dimethoxystyrene (P26) was used as the polymeric backbone and was obtained by a new synthetic route involving the Wittig reaction. The grafting reaction was studied by polymerizing styrene with stannic chloride as catalyst in the presence of various concentrations of preformed P26 in solution with carbon tetrachloride and nitrobenzene at 60, 45, 30, and 0°C. The product was fractionated with cyclohexane and the fractions were analyzed by ultraviolet absorption spectroscopy and density-gradient ultracentrifugation. The molecular termination constant of P26 at 30°C was 0.106 much larger than the value of 0.016 which had been obtained for poly-p-methoxystyrene at 0°C. The amount of grafting and grafting efficiency generally increased with increasing temperature, contrary to results using the cationic initiation reaction. Anomalous results were obtained at 0°C as the product was no longer completely soluble. The ratio of grafted to ungrafted polystyrene chains was proportional to the concentration of P26 and generally increased with temperature. The grafting reaction was competitive with the normal termination reaction, and the energy of activation of the grafting reaction was estimated to be larger by ca. 7 kcal/mole.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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