Publication Date:
1982-05-21
Description:
Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wiley, R G -- Blessing, W W -- Reis, D J -- HL07378/HL/NHLBI NIH HHS/ -- HL18974/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 May 21;216(4548):889-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177039" target="_blank"〉PubMed〈/a〉
Keywords:
*Abrin
;
Animals
;
*Axonal Transport
;
*Lectins
;
Mice
;
Nerve Degeneration/drug effects
;
Neurons/*drug effects
;
*Plant Lectins
;
*Plant Proteins
;
Retrograde Degeneration
;
Ribosome Inactivating Proteins, Type 2
;
*Ricin
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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