Publication Date:
2003-09-06
Description:
Major histocompatibility complex (MHC) class I molecules display tens of thousands of peptides on the cell surface, derived from virtually all endogenous proteins, for inspection by cytotoxic T cells (CTLs). We show that, in normal mouse cells, MHC I molecules present a peptide encoded in the 3' "untranslated" region. Despite its rarity, the peptide elicits CTL responses and induces self-tolerance, establishing that immune surveillance extends well beyond conventional polypeptides. Furthermore, translation of this cryptic peptide occurs by a previously unknown mechanism that decodes the CUG initiation codon as leucine rather than the canonical methionine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwab, Susan R -- Li, Katy C -- Kang, Chulho -- Shastri, Nilabh -- New York, N.Y. -- Science. 2003 Sep 5;301(5638):1367-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12958358" target="_blank"〉PubMed〈/a〉
Keywords:
3' Untranslated Regions
;
Amino Acid Sequence
;
Animals
;
*Antigen Presentation
;
B-Lymphocytes/metabolism
;
Base Sequence
;
Codon, Initiator
;
Codon, Terminator
;
Dendritic Cells/immunology/metabolism
;
Female
;
Fibroblasts/metabolism
;
H-2 Antigens/*immunology
;
Hybridomas
;
Leucine/genetics/metabolism
;
Male
;
Mice
;
Mice, Transgenic
;
Minor Histocompatibility Antigens/genetics
;
Molecular Sequence Data
;
Peptides/*genetics/*immunology
;
*Protein Biosynthesis
;
Proteins/genetics
;
Self Tolerance
;
Spleen/cytology/immunology
;
T-Lymphocytes, Cytotoxic/immunology
;
Transfection
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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