Publication Date:
2002-05-25
Description:
Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus-type 1 (HIV-1) mutations that allow escape from host immune responses may therefore be HLA allele-specific. We analyzed HIV-1 reverse transcriptase sequences from a large HLA-diverse population of HIV-1-infected individuals. Polymorphisms in HIV-1 were most evident at sites of least functional or structural constraint and frequently were associated with particular host HLA class I alleles. Absence of polymorphism was also HLA allele-specific. At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, Corey B -- John, Mina -- James, Ian R -- Christiansen, Frank T -- Witt, Campbell S -- Mallal, Simon A -- New York, N.Y. -- Science. 2002 May 24;296(5572):1439-43.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029127" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Alleles
;
Cohort Studies
;
Consensus Sequence
;
Epitopes, T-Lymphocyte/chemistry/genetics/*immunology
;
Genes, MHC Class I
;
HIV Infections/*immunology/virology
;
HIV Reverse Transcriptase/chemistry/*genetics/immunology
;
HIV-1/*genetics/immunology/physiology
;
HLA Antigens/*genetics/immunology
;
HLA-A Antigens/genetics/immunology
;
HLA-B Antigens/genetics/immunology
;
Humans
;
Logistic Models
;
Multivariate Analysis
;
Mutation
;
*Polymorphism, Genetic
;
RNA, Viral/blood
;
Selection, Genetic
;
T-Lymphocytes, Cytotoxic/*immunology
;
Viral Load
;
Western Australia
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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