Publication Date:
2002-06-29
Description:
Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of their amino acids. To contend with the diversity, country-specific vaccines are being considered, but evolutionary relationships may be more useful than regional considerations. Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaschen, Brian -- Taylor, Jesse -- Yusim, Karina -- Foley, Brian -- Gao, Feng -- Lang, Dorothy -- Novitsky, Vladimir -- Haynes, Barton -- Hahn, Beatrice H -- Bhattacharya, Tanmoy -- Korber, Bette -- N01 AI 85338/AI/NIAID NIH HHS/ -- P20 AI 27767/AI/NIAID NIH HHS/ -- R01 AI 05397/AI/NIAID NIH HHS/ -- R01 AI 35351/AI/NIAID NIH HHS/ -- R01 AI 40951/AI/NIAID NIH HHS/ -- YI AI 1500-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2354-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Los Alamos National Laboratory, Los Alamos, NM 87545, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12089434" target="_blank"〉PubMed〈/a〉
Keywords:
*AIDS Vaccines/immunology
;
Base Sequence
;
Consensus Sequence
;
Cross Reactions
;
Evolution, Molecular
;
Gene Products, env/chemistry/genetics/immunology
;
*Genetic Variation
;
Genome, Viral
;
HIV Antibodies/biosynthesis/immunology
;
HIV Antigens/genetics/immunology
;
HIV Infections/epidemiology/prevention & control/virology
;
HIV-1/classification/*genetics/*immunology
;
Humans
;
Likelihood Functions
;
*Phylogeny
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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