Publication Date:
1992-08-28
Description:
Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the primary mechanism by which these agents produce a selective attenuation of pain (analgesia). NSAIDs are now shown to exert a direct spinal action by blocking the excessive sensitivity to pain (hyperalgesia) induced by the activation of spinal glutamate and substance P receptors. These findings demonstrate that the analgesic effects of NSAIDs can be dissociated from their anti-inflammatory actions. Spinal prostanoids are thus critical for the augmented processing of pain information at the spinal level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malmberg, A B -- Yaksh, T L -- DA02110/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1992 Aug 28;257(5074):1276-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anesthesiology, University of California-San Diego, La Jolla 92093-0818.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1381521" target="_blank"〉PubMed〈/a〉
Keywords:
6-Cyano-7-nitroquinoxaline-2,3-dione
;
Dizocilpine Maleate/pharmacology
;
Dose-Response Relationship, Drug
;
Glutamates/*physiology
;
Glutamic Acid
;
Hyperalgesia/*drug therapy/*physiopathology
;
Ibotenic Acid/analogs & derivatives/pharmacology
;
Injections, Spinal
;
N-Methylaspartate/pharmacology
;
Prostaglandin-Endoperoxide Synthases/*physiology
;
Quinoxalines/pharmacology
;
Receptors, Neurokinin-1
;
Receptors, Neurotransmitter/*physiology
;
Receptors, Tachykinin
;
Substance P/pharmacology
;
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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