Publication Date:
2011-09-10
Description:
How to build and maintain a reliable yet flexible circuit is a fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications to adapt to the changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings in the Drosophila larval visual system, where the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the postsynaptic neuron and concomitant changes to its physiological output. Furthermore, our genetic analyses have identified the cyclic adenosine monophosphate (cAMP) pathway and a previously uncharacterized cell surface molecule as critical components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114502/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114502/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuan, Quan -- Xiang, Yang -- Yan, Zhiqiang -- Han, Chun -- Jan, Lily Yeh -- Jan, Yuh Nung -- 2R37NS040929/NS/NINDS NIH HHS/ -- R37 NS040929/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Sep 9;333(6048):1458-62. doi: 10.1126/science.1207121.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21903815" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Genetically Modified
;
Cyclic AMP/metabolism
;
Darkness
;
Dendrites/*physiology/ultrastructure
;
Drosophila Proteins/genetics/*metabolism
;
Drosophila melanogaster/genetics/growth & development/*physiology
;
Larva/physiology
;
*Light
;
*Light Signal Transduction
;
Membrane Proteins/genetics/*metabolism
;
Mutation
;
*Neuronal Plasticity
;
Neurons/physiology/ultrastructure
;
Photoreceptor Cells, Invertebrate/*physiology/ultrastructure
;
Signal Transduction
;
Synapses/*physiology
;
Visual Pathways
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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