Publication Date:
1979-06-15
Description:
Free-living amoebae of Dictyostelium discoideum aggregate when deprived food, guided by the intercellular transmission of signals of adenosine 3',5'-monophosphate. A succession of multicellular forms is then constructed, each with a circular cross section in every plane normal to its central axis. Amoebae are in constant circular and helical motion around the circumference of these structures. A theory is proposed wherein the sustained progagation of waves of cyclic adenosine 3',5'-monophosphate secretion in cellular loops determines their circumference and thereby organizes morphogenesis in this organism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, R L -- Steck, T L -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1163-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221975" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Aggregation
;
Cell Differentiation
;
Cell Movement
;
Chemotaxis/drug effects
;
Cyclic AMP/pharmacology
;
Dictyostelium/*cytology
;
*Morphogenesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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