ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    The ploidy conveyor of mature hepatocytes as a source of genetic variation (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-24
    Description: Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found in all mammalian species, but the functional significance of this conserved phenomenon remains unknown. Polyploidization occurs through failed cytokinesis, begins at weaning in rodents and increases with age. Previously, we demonstrated that the opposite event, ploidy reversal, also occurs in polyploid hepatocytes generated by artificial cell fusion. This raised the possibility that somatic 'reductive mitoses' can also happen in normal hepatocytes. Here we show that multipolar mitotic spindles form frequently in mouse polyploid hepatocytes and can result in one-step ploidy reversal to generate offspring with halved chromosome content. Proliferating hepatocytes produce a highly diverse population of daughter cells with multiple numerical chromosome imbalances as well as uniparental origins. Our findings support a dynamic model of hepatocyte polyploidization, ploidy reversal and aneuploidy, a phenomenon that we term the 'ploidy conveyor'. We propose that this mechanism evolved to generate genetic diversity and permits adaptation of hepatocytes to xenobiotic or nutritional injury.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967727/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967727/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duncan, Andrew W -- Taylor, Matthew H -- Hickey, Raymond D -- Hanlon Newell, Amy E -- Lenzi, Michelle L -- Olson, Susan B -- Finegold, Milton J -- Grompe, Markus -- DK56338/DK/NIDDK NIH HHS/ -- F32 DK076232-01/DK/NIDDK NIH HHS/ -- F32DK076232/DK/NIDDK NIH HHS/ -- R01 DK067636/DK/NIDDK NIH HHS/ -- R01 DK067636-01/DK/NIDDK NIH HHS/ -- R01DK067636/DK/NIDDK NIH HHS/ -- S10-RR023432/RR/NCRR NIH HHS/ -- England -- Nature. 2010 Oct 7;467(7316):707-10. doi: 10.1038/nature09414. Epub 2010 Sep 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oregon Stem Cell Center, Pape Family Pediatric Research Institute, Oregon Health & Science University, Portland, Oregon 97239, USA. duncanan@ohsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20861837" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Aneuploidy ; Animals ; Chromosome Segregation ; Flow Cytometry ; *Genetic Variation ; Hepatocytes/*cytology/*metabolism ; In Situ Hybridization, Fluorescence ; Karyotyping ; Male ; Mice ; Mitosis ; *Models, Genetic ; *Polyploidy ; Spindle Apparatus/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Consistent patterns of common species across tropical tree communities (2024)
    In:  Nature vol. 625 no. 7996, pp. 728-734
    Details
    Publication Date: 2024-04-13
    Description: Trees structure the Earth's most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations1-6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth's 800 billion tropical trees with trunk diameters of at least 10 cm. Despite differing biogeographic, climatic and anthropogenic histories7, we find notably consistent patterns of common species and species abundance distributions across the continents. This suggests that fundamental mechanisms of tree community assembly may apply to all tropical forests. Resampling analyses show that the most common species are likely to belong to a manageable list of known species, enabling targeted efforts to understand their ecology. Although they do not detract from the importance of rare species, our results open new opportunities to understand the world's most diverse forests, including modelling their response to environmental change, by focusing on the common species that constitute the majority of their trees.
    Keywords: Multidisciplinary ; ABUNDANCE DISTRIBUTIONS ; ALPHA-DIVERSITY ; PLANT DIVERSITY ; FORESTS ; BIOMASS
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER (OA)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...