Publication Date:
2001-11-03
Description:
Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two studies (Schoch et al., Wang et al.) that shed new light on the protein interactions involved in membrane fusion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scales, S J -- Finley, M F -- Scheller, R H -- New York, N.Y. -- Science. 2001 Nov 2;294(5544):1015-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genentech Inc., South San Francisco, CA 94080, USA. sscales@gene.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11691976" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/metabolism
;
Calcium Signaling
;
*Calcium-Binding Proteins
;
Catecholamines/metabolism
;
Cell Membrane/metabolism
;
Cells, Cultured
;
Electrophysiology
;
*Membrane Fusion
;
Membrane Glycoproteins/*physiology
;
Membrane Proteins/*physiology
;
Mice
;
Nerve Tissue Proteins/*physiology
;
Neurotransmitter Agents/metabolism
;
PC12 Cells
;
Phospholipids/metabolism
;
Protein Isoforms
;
R-SNARE Proteins
;
Rats
;
SNARE Proteins
;
Secretory Vesicles/*metabolism
;
Synapses/physiology
;
Synaptic Transmission
;
Synaptic Vesicles/*metabolism
;
Synaptotagmins
;
*Vesicular Transport Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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