Publication Date:
1996-05-24
Description:
Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shibuya, H -- Yamaguchi, K -- Shirakabe, K -- Tonegawa, A -- Gotoh, Y -- Ueno, N -- Irie, K -- Nishida, E -- Matsumoto, K -- New York, N.Y. -- Science. 1996 May 24;272(5265):1179-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8638164" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptor Proteins, Signal Transducing
;
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Carrier Proteins/chemistry/*metabolism
;
Cell Line
;
Cloning, Molecular
;
Enzyme Activation
;
Genes, Reporter
;
Humans
;
*Intracellular Signaling Peptides and Proteins
;
*MAP Kinase Kinase Kinases
;
Mice
;
Molecular Sequence Data
;
Plasminogen Activator Inhibitor 1/genetics
;
Promoter Regions, Genetic
;
Protein-Serine-Threonine Kinases/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Saccharomyces cerevisiae/genetics/metabolism
;
*Signal Transduction
;
Transfection
;
Transformation, Genetic
;
Transforming Growth Factor beta/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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