Publication Date:
2010-07-03
Description:
The identities of the regulators that mediate commitment of hematopoietic precursors to the T lymphocyte lineage have been unknown. The last stage of T lineage commitment in vivo involves mechanisms to suppress natural killer cell potential, to suppress myeloid and dendritic cell potential, and to silence the stem cell or progenitor cell regulatory functions that initially provide T cell receptor-independent self-renewal capability. The zinc finger transcription factor Bcl11b is T cell-specific in expression among hematopoietic cell types and is first expressed in precursors immediately before T lineage commitment. We found that Bcl11b is necessary for T lineage commitment in mice and is specifically required both to repress natural killer cell-associated genes and to down-regulate a battery of stem cell or progenitor cell genes at the pivotal stage of commitment.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935300/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935300/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Long -- Leid, Mark -- Rothenberg, Ellen V -- F06 TW002367/TW/FIC NIH HHS/ -- F06 TW002367-01A1/TW/FIC NIH HHS/ -- R01 GM060852/GM/NIGMS NIH HHS/ -- R01 GM060852-04/GM/NIGMS NIH HHS/ -- R01 GM60852/GM/NIGMS NIH HHS/ -- R33 HL089123/HL/NHLBI NIH HHS/ -- R33 HL089123-03/HL/NHLBI NIH HHS/ -- RC2 CA148278/CA/NCI NIH HHS/ -- RC2 CA148278-02/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2010 Jul 2;329(5987):89-93. doi: 10.1126/science.1188989.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20595614" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
*Cell Lineage
;
Cells, Cultured
;
Down-Regulation
;
Gene Expression Profiling
;
*Gene Expression Regulation, Developmental
;
Genes, T-Cell Receptor delta
;
Genes, T-Cell Receptor gamma
;
Killer Cells, Natural/cytology/physiology
;
*Lymphopoiesis/genetics
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Precursor Cells, T-Lymphoid/cytology/immunology/*physiology
;
Receptors, Antigen, T-Cell, gamma-delta/metabolism
;
Receptors, Notch/metabolism
;
Repressor Proteins/deficiency/genetics/*metabolism
;
Signal Transduction
;
T-Lymphocytes/cytology/metabolism/*physiology
;
Transcription Factors/genetics/metabolism
;
Tumor Suppressor Proteins/deficiency/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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