Publication Date:
1987-10-02
Description:
Interleukin-2 (IL-2) induces cytolytic activity and proliferation of human blood lymphocytes. Yet, prior to activation, these cells do not express IL-2 receptors recognized by monoclonal antibodies to the Tac antigen. A novel glycoprotein (IL-2R beta), identified on several lymphocytoid cell lines, has the ability to bind IL-2 alone and to associate with Tac antigen (IL-2R alpha) to form high-affinity IL-2 receptors. It is now reported that IL-2R beta is expressed on both circulating T lymphocytes and large granular lymphocytes in quantities approximately proportional to their responsiveness to IL-2. Studies of the responses of these cells to IL-2 suggest that IL-2R beta mediates the initial phase of induction of lymphokine activated killer (LAK), natural killer (NK), and proliferative activities. Subsequently, IL-2R alpha is induced and functional high-affinity IL-2 receptors are expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siegel, J P -- Sharon, M -- Smith, P L -- Leonard, W J -- New York, N.Y. -- Science. 1987 Oct 2;238(4823):75-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Virology, Food and Drug Administration, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3116668" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal
;
Cytotoxicity, Immunologic
;
Humans
;
Immunity, Cellular
;
Immunity, Innate
;
Killer Cells, Natural/*immunology
;
*Lymphocyte Activation
;
Lymphocytes/classification
;
Lymphokines/*physiology
;
Macromolecular Substances
;
Receptors, Immunologic/*physiology
;
Receptors, Interleukin-2
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink